Our brains are wired to steer us toward novel experiences. Ogasawara et al. define nodes in a network that underlies novelty-seeking behavior distinct from novelty-orienting responses. In this network, anterior ventral medial temporal cortex (AVMTC) mediates novelty-related sensory processing, and zona incerta uses input from AVMTC to guide gaze shifts for novelty seeking.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Jaegle, A., Mehrpour, V. & Rust, N. Curr. Opin. Neurobiol. 58, 167–174 (2019).
Ogasawara, T. et al. Nat. Neurosci. https://doi.org/10.1038/s41593-021-00950-1 (2021).
Ghazizadeh, A., Griggs, W. & Hikosaka, O. Front. Neurosci. 10, 378 (2016).
Jutras, M. J. & Buffalo, E. A. Proc. Natl. Acad. Sci. USA 107, 401–406 (2010).
Lak, A., Stauffer, W. R. & Schultz, W. eLife 5, e18044 (2016).
Menegas, W., Babayan, B. M., Uchida, N. & Watabe-Uchida, M. eLife 6, e21886 (2017).
Morrens, J., Aydin, Ç., Janse van Rensburg, A., Esquivelzeta Rabell, J. & Haesler, S. Neuron 106, 142–153.e7 (2020).
Matsumoto, M. & Hikosaka, O. Nature 447, 1111–1115 (2007).
Bromberg-Martin, E. S., Matsumoto, M. & Hikosaka, O. Neuron 68, 815–834 (2010).
Tapper, A. R. & Molas, S. Neurobiol. Learn. Mem. 176, 107323 (2020).
Watabe-Uchida, M., Zhu, L., Ogawa, S. K., Vamanrao, A. & Uchida, N. Neuron 74, 858–873 (2012).
Murray, E. A. & Richmond, B. J. Curr. Opin. Neurobiol. 11, 188–193 (2001).
Xiang, J. Z. & Brown, M. W. Neuropharmacology 37, 657–676 (1998).
Acknowledgements
The authors are supported by The Intramural Research Program, National Institute of Mental Health, National Institutes of Health, and Department of Health and Human Services under report ZIAMH 002619. The opinions expressed in this article are the authors’ own and do not necessarily reflect the view of the US National Institutes of Health, the Department of Health and Human Services, or the US Government.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Wang, W., Eldridge, M.A.G. & Richmond, B.J. Novelty seeking for novelty’s sake. Nat Neurosci 25, 7–8 (2022). https://doi.org/10.1038/s41593-021-00965-8
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41593-021-00965-8