Yang et al. demonstrate that sensory neurons are enriched for the anthrax toxin receptor-2. Edema toxin, which acts via this receptor, induces analgesia in mice and can also be engineered to deliver large cargoes such as botulinum toxin in order to selectively silence sensory neurons.
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D.L.B. has acted as a consultant on behalf of Oxford Innovation for Amgen, Bristows, LatigoBio, GSK, Ionis, Lilly, Olipass, Orion, Regeneron and Theranexus over the past two years. He has received research funding from Lilly and an industrial partnership grant from the BBSRC and AstraZeneca. J.P.-S. declares no competing interests.
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Perez-Sanchez, J., Bennett, D.L. Harnessing bacterial toxins to treat pain. Nat Neurosci 25, 132–134 (2022). https://doi.org/10.1038/s41593-021-00981-8
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DOI: https://doi.org/10.1038/s41593-021-00981-8