The discovery of the Tetrahymena group I intron’s self-splicing defined RNAs as capable catalysts. Now, cryogenic electron microscopy structures of this ribozyme have revealed large conformational changes and mechanistic details of its two-step mode of action.
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Cole, K.H., Mogannam, K. & Lupták, A. Choreography of a self-splicing ribozyme. Nat Catal 6, 291–293 (2023). https://doi.org/10.1038/s41929-023-00948-x
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DOI: https://doi.org/10.1038/s41929-023-00948-x