It has long been recognized that some phenotypic variation in mammals cannot be explained by known genetic or environmental variables. Here, the authors show that the absence of Nnat expression is associated with polyphenism in mice with the same genotype. Broadly consistent effects are also found in humans.
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Holland, M.L., Rakyan, V.K. A stochastic basis for metabolic phenotypes. Nat Metab 4, 1091–1092 (2022). https://doi.org/10.1038/s42255-022-00630-9
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DOI: https://doi.org/10.1038/s42255-022-00630-9