The mechanism by which metformin affects food intake remains controversial. Now, two studies link metformin treatment with the induction of the appetite-suppressing metabolite N-lactoyl-phenylalanine, which is produced by the intestine.
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TeSlaa, T. Metformin induces a Lac-Phe gut–brain signalling axis. Nat Metab 6, 603–605 (2024). https://doi.org/10.1038/s42255-024-01014-x
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DOI: https://doi.org/10.1038/s42255-024-01014-x