To demonstrate the long-range effects of CD8+ T cell–secreted interferon-γ on bystander tumor cells, two studies now use mosaic models of antigen loss in tumors combined with intravital imaging. Factors that influence the length scale of diffusible signals could shape disease progression in cancer and autoimmunity.
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Hu, K.H., Krummel, M.F. Carpet-bombing tumors with IFN-γ. Nat Cancer 1, 270–272 (2020). https://doi.org/10.1038/s43018-020-0042-6
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DOI: https://doi.org/10.1038/s43018-020-0042-6