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SYNTHETIC BIOLOGY

Redesigning CO2 fixation

Nature Synthesis volume 1, pages 584–585 (2022)Cite this article

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Nature has evolved several biosynthetic CO2 fixation pathways for the conversion of CO2 into multi-carbon molecules. Now, a synthetic acetyl-CoA bi-cycle is reported that offers increased carbon efficiency by rewiring carbon fixation and non-oxidative glycolysis with implications for industrial gas fermentation.

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Fig. 1: Acetyl-CoA biosynthetic pathways from CO2, with thermodynamic and enzymatic cost analysis.

protein images in dotted circles in panels a and b were created with Biorender.com; panels c and d were reproduced from ref. 8, Springer Nature Ltd.

References

  1. Lüthi, D. et al. Nature 453, 379–382 (2008).

    Article  Google Scholar 

  2. Scown, C. D. & Keasling, J. D. Nat. Biotechnol. 40, 304–307 (2022).

    Article  CAS  Google Scholar 

  3. Preiner, M. et al. Nat. Ecol. Evol. 4, 534–542 (2020).

    Article  Google Scholar 

  4. Russell, M. J. & Martin, W. Trends Biochem. Sci. 29, 358–363 (2004).

    Article  CAS  Google Scholar 

  5. Bar-Even, A., Noor, E. & Milo, R. J. Exp. Bot. 63, 2325–2342 (2012).

    Article  CAS  Google Scholar 

  6. Claassens, N. J., Cotton, C. A. R., Kopljar, D. & Bar-Even, A. Nat. Catal. 2, 437–447 (2019).

    Article  CAS  Google Scholar 

  7. Takors, R. et al. Microb. Biotechnol. 11, 606–625 (2018).

    Article  CAS  Google Scholar 

  8. Wu, C. et al. Nat. Synth. https://doi.org/10.1038/s44160-022-00095-4 (2022).

    Article  Google Scholar 

  9. Ragsdale, S. W. & Pierce, E. Biochim. Biophys. Acta 1784, 1873–1898 (2008).

    Article  CAS  Google Scholar 

  10. Fast, A. G., Schmidt, E. D., Jones, S. W. & Tracy, B. P. Curr. Opin. Biotechnol. 33, 60–72 (2015).

    Article  CAS  Google Scholar 

  11. Bogorad, I. W., Lin, T.-S. & Liao, J. C. Nature 502, 693–697 (2013).

    Article  CAS  Google Scholar 

  12. Song, Y. et al. Proc. Natl Acad. Sci. USA 117, 7516–7523 (2020).

    Article  CAS  Google Scholar 

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  1. Twitter: Michael Köpke

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  1. LanzaTech Inc, Skokie, IL, USA

    Michael Köpke

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  1. Michael Köpke
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Correspondence to Michael Köpke.

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M.K. is an employee of LanzaTech, a for-profit company commercializing gas fermentation.

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Köpke, M. Redesigning CO2 fixation. Nat. Synth 1, 584–585 (2022). https://doi.org/10.1038/s44160-022-00131-3

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