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Heart failure

IGFBP7 on the road to heart failure: driver or passenger?

Nature Cardiovascular Research volume 1, pages 1121–1123 (2022)Cite this article

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Increasing evidence suggests that IGFBP7 may be an accurate biomarker for heart failure. A new study shows that beyond its diagnostic value, IGFBP7 may drive the detrimental effects of pressure overload in mice by a mechanism that, at least in part, involves the regulation of senescence by an IGF-1R–IR–FOXO3a signaling cascade.

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Fig. 1: IGFBP7 as a potential biomediator in heart failure.

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Acknowledgements

This work was supported by FONDAP grant 15130011 (J.R., S.L.) and FONDECYT 11181000 (J.R.) and 1200490 (S.L.).

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Authors and Affiliations

  1. Advanced Center for Chronic Diseases (ACCDiS), Facultad de Ciencias Químicas y Farmacéuticas & Facultad de Medicina, Universidad de Chile, Santiago, Chile

    Jaime A. Riquelme & Sergio Lavandero

  2. Interuniversity Center for Healthy Aging, Santiago, Chile

    Jaime A. Riquelme

  3. Cardiology Division, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA

    Sergio Lavandero

Authors
  1. Jaime A. Riquelme
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  2. Sergio Lavandero
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Correspondence to Sergio Lavandero.

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The authors declare no competing interests.

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Riquelme, J.A., Lavandero, S. IGFBP7 on the road to heart failure: driver or passenger?. Nat Cardiovasc Res 1, 1121–1123 (2022). https://doi.org/10.1038/s44161-022-00189-4

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