Abstract
The authors report five patients with detrusor inactivity in suprasacral spinal cord lesions with perineal spasticity. In all of these cases with cervical or high thoracic lesions treatment with an alpha-blocking drug (Phenoxybenzamine) allowed bladder activity to return. These results suggest that the sacral parasympathetic centre is under the inhibitory influence of the sympathetic nervous system.
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Andersen J T, Bradley W E 1976 The syndrome of detrusor sphincter dyssynergia. Journal of Urology 116:493–495
Bruzelin J M 1981 La pathologie de l'inhibition vésicale. I. L'organisation neurologique de la fonction vésico-sphinctérienne. Journal D'Urologie et de Nephrologie 87:479–506.
De Groat W C, Saum W R 1972 Sympathetic inhibition of the urinary bladder and of pelvic ganglionic transmission in the cat. Journal of Physiology 220:297–314.
Grondard E, Francois N, Maury M, Cukier, J 1978 Les infiltrations para-sphinctériennes anesthésiques du sphincter strié de l'urètre chez le paraplégique. Résultats sur 83 cas. Journal D'Urologie et de Nephrologie 84:207–214
Labat J J, Le Coguic G, Mathe J F, Buzelin, J M 1982 Inactivité du détrusor dans les lésions médullaires centrales. Journal D'Urologie et de Nephrologie 88:527–530
McGuire E J, Wagner F M, Weiss R M 1976 Treatment of autonomic dysreflexia with phenoxybenzamine. Journal of Urology 115:53–55
McGuire E J, Brady S 1979 Detrusor sphincter dyssynergia. Journal of Urology 121:774–777
Nergardh A, Kinn A C H 1983 Neurotransmission in activation of the contractile response in the human urinary bladder. Scandinavian Journal of Urology and Nephrology 17:153–157
Rossier A B, Fam B A, Dibenedetto M, Sarkarati, M 1980 Urethro-vesical function during spinal shock. Urological Research 8:53–65
Rossier A B, Fam B A, Lee I Y, Sarkarati, M, Evans D A 1982 Role of striated and smooth muscle components in the urethral pressure profile in traumatic neurogenic bladders: a neuropharmacological and urodynamic study. Preliminary report. Journal of Urology 128:529–535
Rossier A B, Fam B A, Lee I Y, Sarkarati, M, Evans D A 1983 The respective contribution of smooth and striated components in the urethral pressure profile in the spinal cord injured. A neuropharmacolological and urodynamic study. Paraplegia 21:114–116
Schulman C C, Duarte-Escalante O, Boyarsky S 1972 The ureterovesical innervation. A new concept based on a histochemical study. British Journal of Urology 44:698–712
Willot J P, Maury M 1981 Le passage du drainage à l'autonomie. In: M. Maury (ed) La Paraplégie, pp. 253–259, Flammarion Médecine-Sciences: Paris.
Yalla S V, Blunt K J, Fam B A, Constantinople, N L, Gittes R F 1977 Detrusor urethral sphincter dyssynergia. Journal of Urology 118:1026–1029
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Mathe, J., Labat, J., Lanoiselee, J. et al. Detrusor inhibition in suprasacral spinal cord injuries: is it due to sympathetic overactivity?. Spinal Cord 23, 201–206 (1985). https://doi.org/10.1038/sc.1985.36
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DOI: https://doi.org/10.1038/sc.1985.36