This Milestone is editorially independent, produced with financial support from a third party. About this content.
Milestone animations
Animation | The history of warfarin
This animation illustrates the history and development of warfarin, and its evolution from rat poison to widespread clinical anticoagulant drug.
Animation | Drug targets in the coagulation cascade
This animation illustrates the clotting factors involved in thrombus formation, and how these factors can be pharmacologically targeted using heparin, warfarin, and direct thrombin and factor Xa inhibitors for clinical anticoagulation.
Milestone podcasts
Interview with Jack Hirsh
Listen to Professor Jack Hirsh discuss his involvement in anticoagulant research, including the development of the international normalized ratio.
Interview with Harry Büller
Listen to Professor Harry Büller discuss clinical trials on the prevention and treatment of thrombosis and how medical practice has evolved.
Interview with Jeffrey Weitz
Listen to Professor Jeffrey Weitz discuss the ongoing challenges in anticoagulant therapy and the developments that are on the horizon.
Related multimedia
Poster | Anticoagulant drugs
Nature Reviews Cardiology
Animation | The evolution of oral anticoagulants
Nature Reviews Cardiology & Nature Reviews Drug Discovery
Poster & Animation | The 50-year quest to replace warfarin
Nature Reviews Drug Discovery
PrimeView | Venous thrombosis
Nature Reviews Disease Primers