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This November, world leaders will meet in Glasgow, UK for the 26th Conference of the Parties (COP26) to discuss action on the Paris Agreement and the UN Framework Convention on Climate Change. Science and research played a critical role in identifying and understanding the drivers and impacts of climate change and they are key in delivering solutions to address it. This Collection draws together content from across the Nature Portfolio that discusses solutions to challenges in mitigation, adaptation and finance — key pillars for COP26. The Collection also presents four Q&As with advisors and decision-makers from different parts of the globe on the science–policy interface and their hopes for COP26.