A genome-wide CRISPR/Cas9 screen in osimertinib-treated EGFR mutant cell lines identifies the Hippo pathway as an important non-genetic mechanism of cell survival in persister cells.

The T4SS of RP4, a well-known conjugative plasmid in Gram-negative bacteria, displays a lethal phenotype that is independent of DNA transfer or translocated molecules and is capable of eliminating a range of Gram-negative bacterial species.

In Parkinson’s disease, dopamine intake strengthens cortico-muscular connectivity, enhancing step-timing gait coordination, probably due to sensory-motor integration improvement.

This study reports the direct detection of ribonucleotides embedded in DNA molecules by Oxford Nanopore sequencing, based on ribonucleotides-induced alterations in basecalling features, currents, and dwell times.

A GWAS finds genetic link in ABCC9 gene affecting vocal pitch in both Mandarin and Icelandic speakers, suggesting a shared genetic influence on human vocal systems across populations.

Lipid droplet and palmitic acid accumulation in intervertebral disc degeneration nucleus pulposus cells drive endoplasmic reticulum stress-dependent cellular senescence.

This study focuses on how endothelial cells contribute to ECM accumulation of renal fibrosis and suggests that MDK promotes ACTA2 expression by stabilizing the C/EBPβ protein.

This study identifies a unique “internal-PDZ binding motif” (IPM) of WGEF that mediates its interaction with Dvl2^PDZ, leading to the release of GEF from its autoinhibitory state. It further unravels the underlying mutual Dvl2-IPM recognition aspects.

Circular RNA Circ0075305 hinders gastric cancer stem cells by indirectly increasing the expression of RPRD1A. In turn, RPRD1A disrupts TCF4-β-catenin complex formation and promotes downregulation of SOX9 transcription.

This study established a strategy for systemic administration of prodrugs to induce activation in target neurons in the mammalian brain that express Ionotropic Receptors derived from the insect Drosophila melanogaster.

This comment reports on work done at Harvard Medical School to identify areas for improvement in research rigor, reproducibility, and responsibility in pursuit of continued research excellence.

Documentation of women’s inclusion in Indian academia and conferences by BiasWatchIndia reveals the scale of underrepresentation of women across science, technology, engineering and mathematics.

In 2023, we conducted a virtual program to introduce early-career researchers to the fundamentals of academic journal editing. Here, we reflect on the mission of this program and its outcomes.

A comment article summarizing a range of research activities that contribute to understanding evolving Māori perspectives on Gene Editing and how they might contribute to future regulation.

Nanoparticle therapy continues to be an attractive avenue of targeted and personalised therapies. A molecular nano-conjugate developed by Zeng et al. effectively targets cancer cells and aids in their diagnosis, therapy, and also optimises innate immune responses.