A genome-wide CRISPR/Cas9 screen in osimertinib-treated EGFR mutant cell lines identifies the Hippo pathway as an important non-genetic mechanism of cell survival in persister cells.

The T4SS of RP4, a well-known conjugative plasmid in Gram-negative bacteria, displays a lethal phenotype that is independent of DNA transfer or translocated molecules and is capable of eliminating a range of Gram-negative bacterial species.

In Parkinson’s disease, dopamine intake strengthens cortico-muscular connectivity, enhancing step-timing gait coordination, probably due to sensory-motor integration improvement.

This study reports the direct detection of ribonucleotides embedded in DNA molecules by Oxford Nanopore sequencing, based on ribonucleotides-induced alterations in basecalling features, currents, and dwell times.

A survey of known human DNA editing sites with an RNA editing site prediction algorithm suggests APOBEC-mediated RNA editing may produce some of the same protein variants, with the possibility of affecting multiple areas of health.

High levels of placental growth factor can result in a stiffer microenvironment milieu impeding trophoblast invasion of endometrial cells prior to pregnancy, providing insight into the pathogenesis of pre-eclampsia.

Personalized brain activity models in Alzheimer’s disease detect synergistic amyloid-β and tau impacts on neuronal excitability values, which significantly predict brain atrophy, p-tau217 plasma concentrations, and cognitive deterioration.

The authors present DMD-edited microminipigs showing severe Duchenne muscular dystrophy symptoms; their human-like physiology and small size make them ideal for developing new treatments.

A longitudinal study of the circulatory cellular immunity of individuals co-infected with recurrent visceral leishmaniasis and HIV suggests that T cell unresponsiveness underlies visceral leishmaniasis chronicity.

An fMRI study suggests that adaptation to sensorimotor delays when touching one hand with the other dynamically alters the activity in somatosensory and cerebellar regions.

Documentation of women’s inclusion in Indian academia and conferences by BiasWatchIndia reveals the scale of underrepresentation of women across science, technology, engineering and mathematics.

In 2023, we conducted a virtual program to introduce early-career researchers to the fundamentals of academic journal editing. Here, we reflect on the mission of this program and its outcomes.

A comment article summarizing a range of research activities that contribute to understanding evolving Māori perspectives on Gene Editing and how they might contribute to future regulation.

Nanoparticle therapy continues to be an attractive avenue of targeted and personalised therapies. A molecular nano-conjugate developed by Zeng et al. effectively targets cancer cells and aids in their diagnosis, therapy, and also optimises innate immune responses.

Despite ample investigation on cis-regulatory alterations in evolution, the contribution of these effects to environmental adaptation is poorly understood. Ballinger and colleagues dissected the cis- and trans-regulatory impact on gene expression associated with the adaptation of house mice to temperate and tropical climates, highlighting potential mechanisms acting at a short evolutionary timescale.

The physical properties of the cells and proteins surrounding a tumor play a crucial role in determining the spread of the cancer. How they change cancer cells to suppress the immune response against them is an interesting question addressed in a recent study from Liu et al., which describes how increased stiffness of the tissue around the tumor decreases the amount of a protein—cyclic GMP-AMP synthase—in cancer cells, ultimately blocking the immune response to cancer.