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Developmental changes from birth to 5-years in ASD were associated with a normal physiologic response to chronic excitatory, ATP-related signaling. An inhibitory reversal in this network occurred during typical development that did not occur in ASD.
Piperidine-based ionizable lipids avoid the formation of mRNA–lipid adduct that is responsible for the loss-of-function of mRNA and contribute to the long-term storage stability of mRNA/LNPs as a wet preparation.
This integrative structural biology study elucidates the architecture of the L-A virus at the highest resolution reported to-date. The employed methodology to study yeast cell extracts with minimum perturbation allows exploring protein interactions involved in endogenous virus assembly and function.
Using two-photon fluorescence imaging, the authors show that superoxide anion in hepatic stellate cells impairs the infiltration of CD8+ T cells in a mouse model of hepatocellular carcinoma.
Mathematical models and computer simulations suggest that anti-Hebbian STDP, the type of plasticity observed between cortex and striatum, could support the learning of sequences in the brain.
The article describes the greeting behaviour of elephants and provides an account of first-order intentionality and multicomponent signalling in an animal group other than primates, contributing to our understanding of social signalling in mammals.
A novel method systematically identifies specific biotinylation sites for LC-MS analysis followed by proximity labeling and shows excellent performance compared to related approaches in terms of identification depth with high enrichment power.
Genie, an open-source encoder compliant with ISO/IEC’s MPEG-G standard, delivers state-of-the-art genomic data compression ratios and guarantees long-term data sustainability and decodability through interoperability.
Multiomic study reveals that tumor microenvironmental factors such as hypoxia influence intracellular infection of Fusobacterium nucleatum in colorectal cancer cells and provides clues to malignant transformation of infected cells.
Flexible interareal communication mechanism based on realistic spatiotemporal dynamics of propagating waves of neural population activity, showing how modulating this communication explains various neural effects of attention.
Comparison of the bone phenotypes of hyperthyroid versus euthyroid bone cell-specific conditional knockout mice suggests that the osteoblastic, but not osteoclast, BMP receptor BMPR1A is a main driver of hyperthyroidism-associated bone disease.
A study on global arthropod biodiversity dynamics reveals that beta-diversity increased with latitude, distance, and time. Species replacement and richness difference patterns vary across regions, supporting global biodiversity expectations.
This comment reports on work done at Harvard Medical School to identify areas for improvement in research rigor, reproducibility, and responsibility in pursuit of continued research excellence.
A GWAS finds genetic link in ABCC9 gene affecting vocal pitch in both Mandarin and Icelandic speakers, suggesting a shared genetic influence on human vocal systems across populations.
This study focuses on how endothelial cells contribute to ECM accumulation of renal fibrosis and suggests that MDK promotes ACTA2 expression by stabilizing the C/EBPβ protein.
This study identifies a unique “internal-PDZ binding motif” (IPM) of WGEF that mediates its interaction with Dvl2PDZ, leading to the release of GEF from its autoinhibitory state. It further unravels the underlying mutual Dvl2-IPM recognition aspects.