Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
A study on cryo-EM structural analysis of AFP, including N-glycosylation, fatty acids, and metal ion binding sites, and a systematic comparison with HSA.
GWAS meta-analysis associates 12 sequence variants with essential tremor, identifies seven candidate causal genes including CA3 with multiomics-based analysis, and reveals key roles of dopaminergic and GABAergic neurons in the pathogenesis.
The T4SS of RP4, a well-known conjugative plasmid in Gram-negative bacteria, displays a lethal phenotype that is independent of DNA transfer or translocated molecules and is capable of eliminating a range of Gram-negative bacterial species.
Regulation of siderophore biosynthesis in Shewanella occurs at both transcriptional and post-transcriptional levels by two TCSs, one of which is composed of an orphan phosphorylation-independent RR functioning via a novel mechanism.
G protein-coupled receptors oscillate between inactive and active states, resulting in constitutive activity. Here we show that the calcium-sensing receptor is strongly maintained in the inactive state, resulting in undetectable constitutive activity.
Next-Generation Sequencing and analysis of 16 S rRNA gene from Bengali, Chakma, Marma, Khyang, and Tripura fecal samples revealed a distinct diversity profile of their gut microbiota compared to that of other countries.
A single-cell RNA sequencing reference of six treatment naïve canine osteosarcoma samples. The data presented in this study reveals the presence of 41 cell types and suggests a conserved tumor microenvironment between canine and human osteosarcoma.
The chemokine receptors CCR2 and CCR7 synergistically regulate recruitment of inflammatory monocytes from the bone marrow to the brain of mice infected with La Crosse and Herpes Simplex virus.
A genome-wide CRISPR/Cas9 screen in osimertinib-treated EGFR mutant cell lines identifies the Hippo pathway as an important non-genetic mechanism of cell survival in persister cells.
Presenting a deconvolution algorithm to dissect the bulk proteome by leveraging the information shared between the transcriptome and proteome, the output can be used for further downstream analyses, such as cs-protein Quantitative Trait Loci (cspQTL) mapping and cell type-specific pathology.
A phase-contrast CT study of obstructive biliary disease suggests that the evolution of bile infarct and the formation of infarct-sinusoidal microchannels promote the disease progression.
Nucleic acids-based drugs aim to fix the genetic problem at its source and emerge as a promising new class of drugs. Recent advances in this field enabled their approval for the treatment of orphan genetic diseases for which no cure was available.
This study reports the direct detection of ribonucleotides embedded in DNA molecules by Oxford Nanopore sequencing, based on ribonucleotides-induced alterations in basecalling features, currents, and dwell times.
Exosomes from rats with obstructive sleep apnoea aggravate metabolic dysfunction-associated steatotic liver disease by delivering the lncRNA TCONS_00039830 to hepatocytes and regulating Smad2 expression through targeting miR-455-3p.
Epileptic seizure is one of the symptoms in patients with NGLY1 deficiency, a congenital disorder of deglycosylation. Here the authors show suppressive effects of oxytocin on seizure-like behaviors in a mouse model of NGLY1 deficiency.
PAV-104, a small molecule, potently inhibits SARS-CoV-2 replication in human airway epithelial cells by disrupting viral particle assembly and release. These findings suggest that PAV-104 holds significant promise as a therapeutic for COVID-19.
This study, utilizing deep learning to model semantic saturation, shows its tie to repetitive visual stimuli processing by the primary visual cortex, suggesting a bottom-up neurocognitive process.