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Bispecific antibodies have traditionally been generated by protein engineering, but recently, following developments in the field of site-selective protein modification and bioorthogonal click chemistry, new and improved chemical methods have begun to emerge. These methods offer advantages, including fast reaction times, modularity and the possible attachment of multiple additional cargo, such as dyes and drugs, to the construct. See Szijj & Chudasama
A re-evaluation of the design principles of organocatalysts for atom transfer radical polymerization has led to the development of heteroatom-doped polycyclic arenes as highly active photocatalysts.
An electrosynthetic coupling of olefins with ketones provides an alternative approach to synthesize tertiary alcohols traditionally prepared through Grignard addition to ketones, providing a forward path for an unusual disconnection.
If chemistry is to contribute effectively to the development of a more sustainable world, it is essential that it is taught within a broader socioeconomic and ecological context.
Bispecific antibodies are an up-and-coming type of construct among biologics. They are currently being produced by genetic engineering and expression. This Review highlights recently developed chemical methods for their construction.
DNA is a promising scaffold for guiding biomineralization. This Review describes how DNA nanostructures template calcium-based and silica biominerals, with applications envisioned in biomedicine, electronics and engineering.
Several transition-metal and lanthanide complexes undergo circularly polarized luminescence. This Review describes design principles for the complexes and instruments used to measure them, including in the context of security inks.
Chemical reactions can still occur at temperatures as low as 1 μK. Under such conditions, however, quantum effects are increasingly important, challenging the common understanding of chemical reactivity. The current developments of experimental and theoretical approaches are starting to provide us with a clearer picture of chemistry close to absolute zero.