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Structures, mechanisms and applications of RNA-centric CRISPR–Cas13
CRISPR–Cas13 systems use single-subunit RNA-guided Cas13 effectors for targeted RNA recognition and cleavage. This Review summarizes the recent advances in understanding the structural and mechanistic aspects of Cas13 systems and the diverse applications of these systems in biotechnology and therapeutics.
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Chemical Biology of Microbiomes
Interspecies communication in complex microbiome environments occurs through the small molecules, peptides, and proteins produced by both the host and the microbial residents, as highlighted in this collection of recent articles from Nature Portfolio.
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Discovery of potent inhibitors of α-synuclein aggregation using structure-based iterative learning
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β-Lactone formation during product release from a nonribosomal peptide synthetase
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Molecular recording of calcium signals via calcium-dependent proximity labeling
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Extensive protein pyrophosphorylation revealed in human cell lines