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Time-resolved HT-SAXS discovers allosteric chemotypes for redox target AIF
We present a discovery pipeline integrating chemical fragment screening and time-resolved, high-throughput small-angle X-ray scattering (TR-HT-SAXS). This approach identifies allosteric chemical leads targeting distinct allosteric states of the mitochondrial oxidoreductase apoptosis-inducing factor (AIF). By monitoring kinetic rates of allosteric transition with TR-HT-SAXS, we link fragment structure–activity relationships (SARs) to biomolecular conformation.
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Chemical Biology of Microbiomes
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Programmable synthetic biomolecular condensates for cellular control
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β-Lactone formation during product release from a nonribosomal peptide synthetase
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ATP-competitive inhibitors block protein kinase recruitment to the Hsp90-Cdc37 system
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Structures, mechanisms and applications of RNA-centric CRISPR–Cas13