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Time-resolved HT-SAXS discovers allosteric chemotypes for redox target AIF
We present a discovery pipeline integrating chemical fragment screening and time-resolved, high-throughput small-angle X-ray scattering (TR-HT-SAXS). This approach identifies allosteric chemical leads targeting distinct allosteric states of the mitochondrial oxidoreductase apoptosis-inducing factor (AIF). By monitoring kinetic rates of allosteric transition with TR-HT-SAXS, we link fragment structure–activity relationships (SARs) to biomolecular conformation.
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Chemical Biology of Microbiomes
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Discovery of potent inhibitors of α-synuclein aggregation using structure-based iterative learning
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Programmable synthetic biomolecular condensates for cellular control
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β-Lactone formation during product release from a nonribosomal peptide synthetase
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Molecular recording of calcium signals via calcium-dependent proximity labeling