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Here the authors use on-chip amplitude and phase modulation to synchronously pump a resonator on thin-film lithium niobate for frequency comb generation. They find that pulsed pumping significantly mitigates stimulated Raman scattering and improves the overall efficiency of the device.
Developing stable water oxidation catalysts is of great importance for proton-exchange membrane water electrolyzers. Here the authors report a bicontinuous nanoreactor composed of multiscale defected RuO2 nanocrystals for robust acidic water oxidation reactivity.
The conversion between longitudinal heat flow and transverse charge current is a promising energy harvesting technology. Here, the authors show the large transverse thermoelectric effect induced by the mixed-dimensionality of Fermi surfaces.
Sleepwalking and related parasomnias are associated with partial awakenings out of non-rapid eye movement sleep. Here the authors show that when sleepwalkers have dream-like experiences during their episodes, they display brain activity patterns that resemble those previously described for dreams.
The role of subcellular thermogenesis during neuronal differentiation remains poorly understood. Here, the authors employ methods to monitor local intracellular temperature, and they investigate the effects of non-invasive temperature changes on cell differentiation using neuron-like cells.
Here the authors identify a generic coupling in phase-separated liquids between motility and phase equilibria perturbations: phase-separated droplets swim to their dissolution. This suggests alternative transport mechanism for biomolecular condensates.
Solid polymer electrolytes containing N,N-dimethylformamide (DMF) exhibit improved Li+ conductivity but poor cycle life due to incompatibility between the Li metal anode and DMF. Here, the authors report a polymer electrolyte composited with Hofmann-DMF complex that achieves both high Li+ conductivity and long cycle life.
The ubiquitous second messenger c-di-GMP regulates many biological processes in bacteria, including cell cycle, motility, virulence and biofilm formation. Here, Kaczmarczyk et al. develop a c-di-GMP biosensor that enables dynamic real-time tracking of c-di-GMP levels in individual living cells.
When a solid object is placed in a supersaturated environment, it can exhibit interesting dynamics. Spagnolie et al. conducted an experiment using raisins and 3D-printed bodies in carbonated water and found that the motion of the solid object is influenced by the accumulation and release of bubbles as they reach the surface.
The NF-kB pathway is strictly regulated to prevent excessive inflammatory and immune responses. Here, Li et al. describe an alternative pathway of negative regulation of p65- driven gene expression.
In proteomics, identifying differentially expressed proteins (DEPs) is critical for uncovering biomarkers and drug targets. However, constructing optimal workflows to achieve maximal identification of DEPs is challenging. Here, the authors performed 34,576 combinatorial experiments on 24 gold standard spike-in datasets to discern optimal workflows.
Physicochemical heterogeneity poses a significant constraint in photocatalyst advancement. Here the authors introduce a multimodal optical microscopy platform to assess activity and defects concurrently in photoelectrocatalysts, revealing that disorder can unexpectedly enhance local photoelectrocatalytic performance in certain instances.
The inherent chemical complexity in compositionally complex materials present a challenge in studying atomic diffusion. Here, the authors introduce a neural network kinetics scheme to effectively address this issue and reveal anomalous diffusion behavior in complex concentrated alloys.
The authors show that the presence of strong ocean internal tides in the South China Sea suppresses tropical cyclone intensification, mitigating their impacts on the highly populated surrounding regions.
Hu et al. describe ARTseq-FISH, a spatial omics method that enables multiplexed detection of mRNAs, proteins and phospho-proteins simultaneously and at the same resolution. The authors investigate gene expression changes in a heterogenous colony of micropatterned mESCs.
The epitranscriptome holds many unexplored RNA functions, but detecting multiple modifications from one sample remains challenging. Here, authors devise a strategy combining AI and nanopore sequencing to uncover a transcriptome-wide co-occurrence of two modification types in individual RNA molecules.
Type 2 inflammation drives the formation of pathologic mucus in patients with asthma. Here, authors reveal a role for intelectin-1 in IL-13-induced mucus properties, and that an ITLN1 eQTL is associated with protection from the formation of mucus plugs in T2-high asthma.
Through neutron scattering experiments coupled with machine learning, the authors uncover the strong role of nuclear quantum effects in the dynamics of ammonia in both its solid and technologically relevant liquid phase.