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A major challenge for spin-based information technologies is the generation of spin polarization in otherwise nonmagnetic materials. Here, Arnoldi et al. demonstrate how ultrafast laser excitations can be used to generate spin polarization in a fullerene/tungsten diselenide heterostructure.
Bergenin is a rare C-glycoside of 4-O-methyl gallic acid with multiple pharmacological properties. Here, the authors report the elucidation of the biosynthetic pathway of bergenin in Ardisia japonica and its bioproduction by engineered E. coli.
The factors that determine the direction of traveling waves in the brain are not well understood. Here, the authors show that the sum of incoming structural connection strengths shape both traveling wave direction and frequency gradients.
Even though glucocorticoids are potent anti-inflammatory agents, they can cause muscle wasting. Here, the authors show that targeting the glucocorticoid receptor coactivator LSD1 limits muscle loss without reducing the drugs’ efficiency on the immune system.
The electronic correlation-driven Mott metal-insulator transition has been predicted in a 2D metal-organic framework with a kagome structure. Here the authors synthesize such a system in experiment and demonstrate an electrostatically controlled Mott transition.
The regulatory mechanism and functional consequence of lysine lactylation remain to be explored. Here, the authors identify HBO1 as a lysine lactyltransferase and suggest a potential role of HBO1 in tumorigenesis through H3K9la-mediated transcription regulation.
Tuning the physical interactions and structures to govern the viscoelastic properties in hydrogels without altering the chemistry is challenging. Here the authors design a complexation gel composite and utilize the physical principle of topologically frustrated dynamical state to tune the correlated structures between the guest polycation chains and negatively charged host gels.
Here, the authors perform large trans-ancestry fine-mapping analyses identifying large numbers of association signals and putative target genes for colorectal cancer risk, advancing our understanding of the genetic and biological basis of this cancer.
Triacylglycerol remodeling in Physaria fendleri changes the seed oil fatty acid composition after initial synthesis to overcome metabolic bottlenecks in the accumulation of valuable unusual fatty acids. This process enhances designer oil engineering.
A regulated stress response is essential for healthy child growth and development. Here, the authors show that a nutrition, water, sanitation, and hygiene intervention enhanced adaptive responses of the physiological stress system in early childhood.
Rare disease DEDSSH1-associated DPH1 mutations impair eEF2 diphthamide modification that leads to eEF2 as a transcriptional coactivator for p53 to enhance expression of the cell proliferation inhibitor p21, resulting in birth defects.
Confining atoms to lattices can modify their interaction and collision. Here the authors show suppression of dipolar relaxation in the form of reduced decay rate of dysprosium atoms in quasi-2D regime.
Oxygen is an essential requirement for aerobic organisms. Here the authors explore the role of oxygen in the antiviral innate response in multiple models of infection and suggest oxygen enhances the antiviral innate response via EGLN1 hydroxylation of IRF3.
The surface charge and ζ-potential of biomolecular condensates is key to their interactions with membranes and proteins. Here, the authors developed a method to determine the ζ-potential of condensates using microelectrophoresis and single-droplet tracking.