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The epitranscriptome holds many unexplored RNA functions, but detecting multiple modifications from one sample remains challenging. Here, authors devise a strategy combining AI and nanopore sequencing to uncover a transcriptome-wide co-occurrence of two modification types in individual RNA molecules.
CALF-20 is a water stable structure capable of selectively separating CO2 from flue gas. Here authors use a close feedback loop between theory and experiments to understand CO2/water adsorption and framework flexibility of CALF-20.
Room temperature phosphorescent materials have many desirable properties, but fine control of these can be challenging. Here, the authors report a strategy for this control by dynamic lanthanide coordination in combination with organic phosphors.
The synthesis of covalent organic frameworks (COFs) by a soft-template methodology is challenging. Here, the authors attach the soft templates to the COFs backbone via ion bonds, avoiding crystallization incompatibilities and allowing subsequent removal of the template by ion exchange for enhanced U(VI)/Th(IV) adsorption performance.
Human glial progenitor cells (hGPCs) lose mitotic competence with age. Here, the authors show that with maturation, adult hGPCs acquire a set of transcriptional repressors that actively suppress developmental gene expression.
The LINE-1 retrotransposon is a target for the development of therapies to treat age-associated disease. Here the AUs describes the characterization of small molecule inhibitors of the endonuclease domain of LINE-1.
Here, Xian et al. use phosphoproteomics to identify that the Shigella effector OspG interacts with a regulator of Cullin-RING ubiquitin ligases to promote the ubiquitination of septins and consequent inhibition of septin cage formation.
This study presents an unprecedented analysis of agricultural land multi-degradation in 40 European countries, using twelve dataset-based processes that were modelled as land degradation convergence and combination pathways across the continent.
Autologous tumor lysate (ATL) dendritic cell (DC) vaccination can induce local and systemic anti-tumor immune responses in malignant glioma patients. In this randomized phase II clinical trial, the authors evaluate the effectiveness of adding the TLR agonists, poly-ICLC or resiquimod, to ATL-DC vaccination in patients with newly-diagnosed or recurrent WHO Grade III-IV malignant gliomas.
The inherent instability of poly(sulfur) renders the conversion of elementary sulfur into sulfur-rich polymers challenging which limits the use of this industrial by-product. Here, the authors demonstrate that inorganic sulfur can be utilized by copolymerizing with cyclic disulfides, producing high-performance thermoplastic elastomers with self-healing ability and degradability.
In this work, authors propose a flash Joule heating-based process for meat preservation, enabled by the formation of a thin, microbe-inactivated, and dehydrated layer on the surface. The method is energetically efficient and shown to significantly extend the food shelf life while maintaining food freshness.
Immune checkpoint inhibition is a successful form of immune therapy; however response rates vary widely among individual patients. Here authors show that circulating small extracellular vesicles might contribute to poor response to anti-PD-1 treatment by carrying PD-1 and CD80 which results in higher level of vesicular PD-L1 expression in the circulation at the expense of expression on tumour cell membranes, causing immunosuppression.
The F-box domain is a conserved structural motif in ubiquitin ligases known only to bind Skp1. Here, the authors show the F-box domain is also an environmental cadmium sensor that changes conformation upon binding to disassemble the active ligase, protecting the cell from cadmium stress.
To measure temperatures close to absolute zero, authors developed a kind of composite phase diamond (CPD) that can measure temperature at the millikelvin level, making it a promising candidate for next–generation cryogenic temperature sensors.
KtrAB complex is essential in K+ uptake for bacteria. Here authors illustrate the synergism of ATP and Na+ in activating K+ uptake of KtrAB from Bacillus subtilis and its gating mechanism, which may also shed light on other Na+-activated K+ channels.
Primaquine treatment for breastfeeding mothers is currently not recommended. Here, the authors develop a pharmacokinetic model to predict drug exposure of infants and show that ingesting breastmilk from mothers treated with primaquine results in <1% of maternal drug exposure. This suggests that primaquine should not be restricted in post-neonatal breastfeeding women as standard doses are unlikely to cause adverse events in infants.
The authors study a YbCoIn5/CeCoIn5/YbRhIn5 heterostructure. Using non-reciprocity in the second harmonic transport response, they demonstrate the existence of a specific form of finite-momentum pairing called a helical superconducting state, where the phase of the order parameter is spontaneously spatially modulated.
As quantum simulations advance, the ability to measure response functions of simulated systems becomes increasingly important. Here the authors present a linear response framework for computing fermionic and bosonic response functions on a quantum computer, demonstrating advantages over existing methods.
Engineering of a biosensor allows the authors to map the signaling activity of the phytohormones gibberellins (GAs) and to show that GAs orient cell division at the shoot apex to establish the organization in parallel cell files of plant stems.
So far, only homoleptic N2 complexes of silicon have been reported under matrix-isolation conditions including but the activation of more inert nitrogen by silylenes remains challenging. Here the authors report on the activation of dinitrogen by silylenes under cryogenic conditions.