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Transient synaptic CD61 pairing with CD103 increases the cytotoxicity of antigen-specific T cells
The transient expression of CD61 and its unconventional pairing with CD103 at the immune synapse enhances T cell receptor signaling, improves anti-tumor cytotoxicity and mitigates tumor growth. Clinically, CD61+ tumor infiltrating lymphocytes (TILs) exhibit enhanced effector functions and show limited cellular exhaustion.
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SARS-CoV-2 reservoir in post-acute sequelae of COVID-19 (PASC)
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Hepatocytes coordinate immune evasion in cancer via release of serum amyloid A proteins
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JAK-STAT signaling maintains homeostasis in T cells and macrophages
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Apolipoprotein E controls Dectin-1-dependent development of monocyte-derived alveolar macrophages upon pulmonary β-glucan-induced inflammatory adaptation