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Neurons positive for III-tubulin expressing tyrosine hydroxylase after serial induction and differentiation in astrocyte coculture. In this issue, Goldman and colleagues show that these neurons can induce recovery in a model of Parkinson disease, but highlight their potential to become tumorigenic. Photo courtesy of Steven Goldman.
Spooked by reports that vaccines might cause diseases such as autism, many parents choose not to vaccinate their kids. But when their decision endangers others, asks Virginia Hughes, should the government step in?
The first woman to head Paris's prestigious Institut Pasteur, Alice Dautry inherited an ugly mess. One year into the job, she has already succeeded in getting the center back on track.
The goal of replacing dying cells in Parkinson disease with stem cells is now brought a step closer to the clinic. A new protocol eases symptoms in a rat model of the disease, but also raises the concern that poorly differentiated cells have the potential to become tumorigenic (pages 1259–1268).
A molecular basis for the metabolic abnormalities observed in Huntington disease is emerging. Transcription of a key mitochondrial regulator, PGC-1α, is dysregulated by mutant huntingtin, leading to oxidative stress and excitotoxicity. The findings dovetail with previous work implicating aberrant transcription in Huntington disease, and have implications for related conditions such as Parkinson disease.
Blockade of a single cytokine—interleukin-10—can re-energize T cells 'exhausted' by persistent virus infection. The findings have implications for controlling HIV and other persistent viruses (pages 1301–1309).