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Increased relative abundance of oral bacteria in faecal samples can be explained by the marker hypothesis—their relative increase reflects the depletion of other microbiota members—which has implications for patient outcomes and microbiota-directed therapies.
Exoglycosidases isolated from the mucolytic gut bacteria Akkermansia muciniphila bring enzymatic conversion of A and B blood group erythrocytes to blood group O a step closer.
Discovery, biochemical and structural characterization of exoglycosidases from Akkermansia muciniphila reveals combinations that efficiently target extended A and B blood group antigens to produce ABO-universal blood for transfusions.
Analyses refuting the dogma that a quarter of the world’s population is latently infected with Mycobacterium tuberculosis emphasize the need for a redirection of research priorities.
Analysis of Mycobacterium tuberculosis-specific antibody responses in previously exposed South African cohorts reveals that profile features associated with progression to active tuberculosis are affected by age and sex.
SARS-CoV-2 infection can be associated with ‘brain fog’ and persistent neurologic disease, especially in the elderly, with the possibility of direct viral particle interference with normal synaptic transmission.
IFITM1 can compete with EBV glycoproteins for EphA2 binding and prevent virus entry into epithelial cells, in vitro and in vivo. YTHDF3 suppresses IFITM1 via the degradation-related protein DDX5.
Comparing infection routes and subsequent transmission of MPXV in the multimammate rat (Mastomys natalensis) indicates increased susceptibility, shedding and transmission via the genital mucosae.
Antibiotics to treat carbapenem-resistant Acinetobacter baumannii infection are an urgent need. The cerastecins are potent, bactericidal and efficacious in animal models of infection, and may enable new treatment modalities targeting LOS transport.
Targeted accurate RNA consensus sequencing enables study of de novo errors caused by RNA-dependent RNA polymerases and provides deeper insights into how SARS-CoV-2 genetic diversity emerges.
Nematode signals such as ascarosides are sensed by G protein-coupled receptors of a nematode-trapping fungus, resulting in fungal activation of cAMP–PKA signalling and trap development.
We characterize the activity of fluorofolin, a potent inhibitor of dihydrofolate reductase, against Pseudomonas aeruginosa. By exploiting a divergence in thymidine metabolism, fluorofolin becomes selective for P. aeruginosa in the presence of thymine, demonstrating that it can be a narrow-spectrum antibiotic for this bacterial pathogen.
Diet switching from high-fat to standard diet before influenza vaccination affects the metabolic state of T cells, restores their responses and improves vaccine efficacy in mice.
Artemisinin-resistant Plasmodium falciparum can use tRNA modification reprogramming and codon bias translation as an epitranscriptomic response to survive artemisinin-induced stress.
CryoEM of the Salmonella MS- and C-rings in a counterclockwise pose and the C-ring in clockwise poses reveal structural insight into the mechanisms of directional switches and torque transmission for the bacterial flagellar supercomplex.