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A study shows that application of spatiotemporally patterned epidural electrical stimulation alongside rehabilitation allowed individuals with spinal cord injury and severe locomotor deficits to walk with limited assistance.
Two studies show that tau pathology drives the expression of complement molecules that in turn promote the phagocytosis of synapses and neuroinflammation.
Dopamine released in the rodent prefrontal cortex increases the signal-to-noise ratio of responses to aversive stimuli that are transmitted to the periaqueductal grey.
Maladaptive modulation of learning, memory and affect by opioids is linked to dysfunctional neurogenesis. In this Review, Kibaly and colleagues discuss this link and how strategies that target neurogenesis to rescue opioid-dependent learning, memory and affect impairments constitute future directions for anti-addiction therapies.
Necroptosis is a form of cell death mediated by receptor-interacting protein kinase 1 (RIPK1), and is observed in several CNS disorders. Here, Yuan, Amin and Ofengeim give an overview of necroptosis in the CNS and explain its relationship with inflammation in CNS disorders.
Neural stem and progenitor cells can be regulated through mitochondrial signalling mechanisms and this has major implications in physiological and pathological conditions. In this Review, Khacho and colleagues discuss how mitochondria can serve as signalling organelles that modify the fate of stem cells in the brain.
Many neurobiological processes are regulated on a circadian basis. Circadian rhythms change during development, into adulthood and with ageing, when certain disorders typically emerge. Here, Logan and McClung give an overview of the relationship between the circadian system and brain disorders across various life stages.
