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Granzyme serine proteases in inflammation and rheumatic diseases
Granzyme serine proteases are known for their perforin-dependent cytotoxic activities, but evidence also indicates that they have a range of non-cytotoxic, pro-inflammatory intracellular and extracellular functions. In this Review, the authors discuss granzyme biology with an emphasis on its involvement in rheumatic disease pathology.
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25 years of biologic therapy
Biologic therapies with various modes of action have been introduced into the field of rheumatology over the past 25 years, and have revolutionized the treatment and outcomes in many rheumatic diseases. This collection from Nature Reviews Rheumatology brings together articles on biologic therapy in rheumatology, including the latest Reviews and Opinion pieces, as well as popular content from our archives.
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Global epidemiology of gout: prevalence, incidence, treatment patterns and risk factors
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Hand osteoarthritis: clinical phenotypes, molecular mechanisms and disease management
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Treat-to-target or treat-to-dissolve strategy to improve gout treatment
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Granzyme serine proteases in inflammation and rheumatic diseases