Disentangling channel gating mechanisms
Kalienkova et al. report structures of an FMRFamide-gated sodium channel (FaNaC) in several functional states, disentangling how different invertebrate receptors recognize similar neuropeptides.
Kalienkova et al. report structures of an FMRFamide-gated sodium channel (FaNaC) in several functional states, disentangling how different invertebrate receptors recognize similar neuropeptides.
Systemic RNA interference (RNAi) in Caenorhabditis elegans is initiated by SID-1-mediated double-stranded RNA (dsRNA) internalization. By combining cryo-electron microscopy (cryo-EM), in vitro and in vivo assays, we show how SID-1 specifically recognizes dsRNA and provide important insights into dsRNA internalization by SID-1.