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Immunofluorescence staining of extended chromatin fibers (colored lines) and metaphase chromosomes (center) indicate that histone modification in human and fly centromeric chromatin (red regions) is distinct from that of both euchromatin and the flanking heterochromatin. pp 1076-1083.
A combined structural and biochemical analysis of an essential stress protein in Escherichia coli provides the first detailed insights into a bacterial translation mechanism designed to cope with cold shock conditions.
Recent characterization of two distinct signals leading to IRF-3 activation in response to double-stranded RNA recognition by Toll-like receptor 3 provides new mechanistic information on the regulatory events that link the detection of viral invasion by the cell with the development of the antiviral response.
A new report provides evidence that the TFIIB-RNAPII interaction depends on the presence of additional factors and highlights the importance of structural characterization of the entire preinitiation complex.
Retrovirus particles contain a dimeric form of their genomic RNA. A recent study suggests a mechanism that might underlie the selective incorporation of dimeric RNAs into assembling virus particles.