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EaSeq, a user-friendly and freely available software tool, offers fast and comprehensive ChIP-Seq data analyses, enabling researchers to easily generate hypotheses from genome-wide datasets. Cover image by Mads Lerdrup. (p 349)
Structures of the human orexin receptor 1 (hOX1R) bound to a selective drug and the dual (hOX1R- and hOX2R-targeting) antagonist suvorexant reveal molecular mechanisms of selectivity in orexin-receptor subtypes.
Three recent reports explore how PRDM9 binds to meiotic hotspots within the genome and provide compelling evidence that hotspot erosion leads to speciation.
USP7 deubiquitinase is now shown to prevent ubiquitination of SUMO chains of replisome proteins, thereby regulating DNA replication-fork progression and origin firing.
NMR approaches are used to probe cotranslational folding of a nascent polypeptide with two domains in Escherichia coli. The work reveals that interactions with the ribosome inhibit acquisition of the native fold by the nascent chain.
New evidence that human telomerase RNA (hTR) degradation by EXOSC10 or DCP2 and XRN1 reduces telomerase activity when dyskerin is compromised suggests that RNA decay pathways may provide future therapeutic targets for telomere biology disorders.
Human orexin receptors (hOX1R and hOX2R) are GPCRs involved in sleep regulation. Structures of hOX1R bound to a selective antagonist or to a dual antagonist, functional assays and computational analyses reveal the basis for subtype selectivity.
Structural and cellular analyses reveal that the presence of an isoform-specific α-helix in myosin VI determines whether this motor protein functions in endocytosis or cell migration.
The crystal structure of human YL1, here established as an H2A.Z-deposition chaperone, in complex with an H2A.Z–H2B dimer reveals the molecular basis for the specificity of H2A.Z recognition.
The crystal structure of Drosophila melanogaster YL1 in complex with an H2A.Z–H2B dimer exposes a selective recognition mechanism distinct from those of other H2A.Z chaperones and suggests a hierarchical transfer mechanism mediating H2A.Z deposition.
Cancer-associated point mutations in the scaffold protein Axin derail Wnt signaling and promote tumor growth through formation of nonamyloid nanoaggregates that rewire the Axin interactome.
Monitoring ribosomal translocation from five structural perspectives with pre–steady state smFRET defines intramolecular conformational events within the EF-G–GDP–bound ribosome as rate-determining steps of directional substrate translocation.
Ensemble kinetics and FRET analyses reveal the sequence of collective motions on the E. coli ribosome during translocation promoted by EF-G and allow identification of a new early forward swiveling of the SSU head.
EaSeq, a user-friendly and freely available software tool, offers fast and comprehensive ChIP-sequencing data analyses, enabling experimentalists to easily extract information and generate hypotheses from genome-wide datasets.
