The sirtuin proteins have emerged as potential regulators of mammalian lifespan, and are believed to be responsible for the health and longevity-enhancing effects of caloric restriction. Here, Baur and colleagues provide an overview of the sirtuin family, focusing on sirtuin 1 (SIRT1) and its potential to be targeted in the treatment of age-related diseases. They address the controversy surrounding the mechanism of action of resveratrol and the development of more potent SIRT1 activators.
- Joseph A. Baur
- Zoltan Ungvari
- Rafael de Cabo