Circadian rhythms articles from across Nature Portfolio

Maternal circadian rhythms influence the health of infants. Cui, Xu and colleagues find that disruption of maternal rhythms impairs neonatal immune cell function and aggravates neonatal inflammatory disorders, which can be rescued by the administration of docosahexaenoic acid (a metabolite found in breast milk).

Age has an impact on circadian rhythm. Here, the authors report that LKRSDH-dependent H3R17me2 and H3K27me3 at insulin-like peptide sites contribute to age-related circadian rhythm change in Drosophila.

In mice, disruption of circadian rhythms during pregnancy aggravates neonatal inflammation via metabolic reprograming of myeloid cells in the offspring.

A canonical circadian clock component in C. elegans was identified after decades of research: mammalian Ror homolog, nhr-23. It is essential for both the 8-h developmental rhythm and 24-h circadian rhythm.

Maternal circadian rhythms influence the health of infants. Cui, Xu and colleagues find that disruption of maternal rhythms impairs neonatal immune cell function and aggravates neonatal inflammatory disorders, which can be rescued by the administration of docosahexaenoic acid (a metabolite found in breast milk).

Class 3 phosphatidylinositol-3-kinase (PI3K) has a surprising nuclear function as a coactivator of the circadian clock Bmal1–Clock transcription factor complex for rhythmic purine nucleotide metabolism. This finding opens new avenues for establishing the roles of nuclear subunits of class 3 PI3K in metabolic homeostasis.

Time-restricted eating, a form of intermittent fasting, has shown promise in promoting metabolic health. In mice, limiting food accessibility only to the active cycle reduces body weight and improves glucose homeostasis; now, Xin et al. show that restricting feeding to the resting period increases their running performance.

A study using a multi-organoid platform and state-of-the-art transcriptional profiling identifies potential therapeutic targets against SARS-CoV-2. The authors find that CIART, a gene involved in circadian regulation, promotes SARS-CoV-2 infection by regulating the retinoid X receptor pathway and fatty acid synthesis.

Myocardial ischemia–reperfusion injury is more severe during the sleep-to-wake transition period of the day. A new study shows that timed administration of digoxin, a cardiac glycoside approved by the US Food and Drug Administration, prevents experimental myocardial ischemia–reperfusion injury by controlling proteostasis of the circadian-clock regulator Rev-Erbα.