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Developmental biology is the field of biology that studies the processes by which multicellular organisms grow and develop, controlled by their genes. Knowledge of normal developmental processes can aid in the understanding of developmental abnormalities and other conditions such as cancer.
Multicellular modeling is increasingly being used to understand biological systems. SimuCell3D is a tool that allows mechanically realistic simulations, using the deformable cell model, to be developed and run.
Skeletal muscle is a highly heterogenous tissue that comprises multiple cell types. Leveraging single-cell and single-nucleus experiments, we systematically mapped the cellular and molecular changes across different skeletal muscle compartments with age. We identify neuromuscular-junction accessory nuclei that may be pivotal in mitigating denervation and uncovered differences between myofiber and myonucleus aging.
The sympathetic nervous system, which enables the fight-or-flight response, was thought to be present only in jawed vertebrates. Analysis of a jawless vertebrate suggests that this system might be a feature of all animals with a spine.
Yang, Golkaram et al. reported that in human embryonic stem cells, cellular crowding leads to the blockade of FGFR1 endocytosis, resulting in a decrease in ETV4 expression. This, in turn, derepresses the neuroectoderm fate.
Here the authors show that DNA translesion synthesis affects primordial germ cell DNA demethylation and plays a role in the development of embryonic germ cells.
This protocol details the generation of cortical organoids with complex neural oscillations through a ‘semi-guided’ protocol, and their functional characterization using microelectrode array measurements, calcium imaging and adeno-associated virus transduction.
A cure for diabetes could entail an effective cell replacement therapy through generation of new insulinproducing cells. In this study, we show that inhibition of focal adhesion kinase activity results in transdifferentiation of a subset of peri-islet acinar cells into functional insulin producing β-like cells.
“A transcriptome study of chicken primary myoblast proliferation and differentiation shows that the lncMDP1/miRNA-301a-5p/CHAC1 axis plays an important role in skeletal muscle development.“
Multicellular modeling is increasingly being used to understand biological systems. SimuCell3D is a tool that allows mechanically realistic simulations, using the deformable cell model, to be developed and run.
The science of sex and gender is too often misinterpreted and weaponized. Now, three experts cut through the misinformation in search of a positive future for this long-neglected area of research
Social robots that promise companionship and stimulation for older people and those with dementia are attracting investment, but some question their benefits.
Skeletal muscle is a highly heterogenous tissue that comprises multiple cell types. Leveraging single-cell and single-nucleus experiments, we systematically mapped the cellular and molecular changes across different skeletal muscle compartments with age. We identify neuromuscular-junction accessory nuclei that may be pivotal in mitigating denervation and uncovered differences between myofiber and myonucleus aging.