Featured
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Article
| Open AccessHMGN1 loss sensitizes lung cancer cells to chemotherapy
- Xianli Wu
- , Geqi Cai
- & Wenchu Lin
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Editorial
| Open AccessMitochondrial dynamics: updates and perspectives
Mitochondria, the powerhouse and the vital signaling hub of the cell, participate in a variety of biological processes, such as apoptosis, redox responses, cell senescence, autophagy, and iron homeostasis. Mitochondria form a mostly tubular network, made up of an outer and a cristeae-forming inner membrane. The network undergoes dynamic fusion and fission that change its morphological structure according to the functional needs. Approximately 1500 mitochondrial proteins encoded by nuclear genome plus over 10 proteins encoded by mitochondrial DNA are folded and assembled in the mitochondria under a high-fidelity control system. These proteins are involved in oxidative phosphorylation, metabolism, network and cristae dynamics, mitophagy, import machinery, ion channels, and mitochondrial DNA maintenance. This Collection gathers original research that advances our understanding of the monitoring techniques and pathophysiological significance of mitochondrial dynamics in health and disease.
- Kezhong Zhang
- & Ježek Petr
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Article
| Open AccessDroplet based whole genome amplification for sequencing minute amounts of purified Mycobacterium tuberculosis DNA
- Anzaan Dippenaar
- , Nabila Ismail
- & Robin M. Warren
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Article
| Open AccessBody mass index is an overlooked confounding factor in existing clustering studies of 3D facial scans of children with autism spectrum disorder
- Martin Schwarz
- , Jan Geryk
- & Veronika Moslerová
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Article
| Open AccessMiR-204-5p may regulate oxidative stress in myopia
- Bo Jiang
- , Nan Hong
- & Feng Dong
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Article
| Open AccessTreadmill training improves lung function and inhibits alveolar cell apoptosis in spinal cord injured rats
- Xianbin Wang
- , Yingxue Fu
- & Shuang Wu
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Article
| Open AccessS100a9 might act as a modulator of the Toll-like receptor 4 transduction pathway in chronic rhinosinusitis with nasal polyps
- Nasibeh Khayer
- , Maryam Jalessi
- & Zahra Azad
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Article
| Open AccessPredicting FFAR4 agonists using structure-based machine learning approach based on molecular fingerprints
- Zaid Anis Sherwani
- , Syeda Sumayya Tariq
- & Zaheer Ul-Haq
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Article
| Open AccessXPO1 blockade with KPT-330 promotes apoptosis in cutaneous T-cell lymphoma by activating the p53–p21 and p27 pathways
- Nitin Chakravarti
- , Amy Boles
- & Pierluigi Porcu
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Article
| Open AccessAn increase in ER stress and unfolded protein response in iPSCs-derived neuronal cells from neuronopathic Gaucher disease patients
- Tanapat Pornsukjantra
- , Nongluk Saikachain
- & Nithi Asavapanumas
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Article
| Open AccessMolecular epidemiology and hematological profiles of hemoglobin variants in southern Thailand
- Wanicha Tepakhan
- , Sataron Kanjanaopas
- & Saristha Buathong
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Article
| Open AccessSMS121, a new inhibitor of CD36, impairs fatty acid uptake and viability of acute myeloid leukemia
- Hannah Åbacka
- , Samuele Masoni
- & Karin Lindkvist-Petersson
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Article
| Open AccessC16, a PKR inhibitor, suppresses cell proliferation by regulating the cell cycle via p21 in colorectal cancer
- Yu Hashimoto
- , Yoshio Tokumoto
- & Yoichi Hiasa
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Article
| Open AccessAnalysis of plasma metabolomes from 11 309 subjects in five population-based cohorts
- Nilanjana Ghosh
- , Carl Lejonberg
- & J. Gustav Smith
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Article
| Open AccessMolecular detection of exosomal miRNAs of blood serum for prognosis of colorectal cancer
- Tahani Bakhsh
- , Safiah Alhazmi
- & Ahmed Bahieldin
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Article
| Open AccessTranscriptomics analysis of long non-coding RNAs in smooth muscle cells from patients with peripheral artery disease and diabetes mellitus
- Yankey Yundung
- , Shafeeq Mohammed
- & Jaroslav Pelisek
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Article
| Open AccessMetabotropic glutamate receptor genetic variants and peripheral receptor expression affects trait scores of autistic probands
- Nilanjana Dutta
- , Mahasweta Chatterjee
- & Kanchan Mukhopadhyay
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Article
| Open AccessThe polymorphism analysis for CD36 among platelet donors
- Qilu Lyu
- , Yuwei Lin
- & Jue Wang
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Article
| Open AccessPossible involvement of zinc transporter ZIP13 in myogenic differentiation
- Masaki Shoji
- , Takuto Ohashi
- & Takashi Kuzuhara
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Article
| Open AccessIntranasal administration of ceramide liposome suppresses allergic rhinitis by targeting CD300f in murine models
- Takuma Ide
- , Kumi Izawa
- & Jiro Kitaura
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Article
| Open AccessM1 macrophages polarized by crude polysaccharides isolated from Auricularia polytricha exhibit anti-tumor effect on human breast cancer cells
- Sunita Nilkhet
- , Kuljira Mongkolpobsin
- & Siriporn Chuchawankul
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Article
| Open AccessRSAD2 is abundant in atherosclerotic plaques and promotes interferon-induced CXCR3-chemokines in human smooth muscle cells
- Assim Hayderi
- , Ashok K. Kumawat
- & Liza U. Ljungberg
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Article
| Open AccessIntra-articular injection of miRNA-1 agomir, a novel chemically modified miRNA agonists alleviates osteoarthritis (OA) progression by downregulating Indian hedgehog in rats
- Pengcui Li
- , Yangyang Gao
- & Xiaochun Wei
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Article
| Open AccessTargeted phasing of 2–200 kilobase DNA fragments with a short-read sequencer and a single-tube linked-read library method
- Veronika Mikhaylova
- , Madison Rzepka
- & Zhoutao Chen
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Article
| Open AccessNeuroprotective mechanisms of luteolin in glutamate-induced oxidative stress and autophagy-mediated neuronal cell death
- Wudtipong Vongthip
- , Sunita Nilkhet
- & Seung Joon Baek
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Article
| Open AccessClinically significant changes in genes and variants associated with epilepsy over time: implications for re-analysis
- Alan J. Robertson
- , Khoa A. Tran
- & Nicola Waddell
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Article
| Open AccessTenovin 3 induces apoptosis and ferroptosis in EGFR 19del non small cell lung cancer cells
- Sha Lv
- , Qianrong Pan
- & Xueping Lei
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Article
| Open AccessNeutrophil to lymphocytes ratio in deep infiltrating endometriosis as a new toll for clinical management
- Mattia Dominoni
- , Marianna Francesca Pasquali
- & Barbara Gardella
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Article
| Open AccessThe cyclooxygenase-2 upregulation mediates production of PGE2 autacoid to positively regulate interleukin-6 secretion in chronic rhinosinusitis with nasal polyps and polyp-derived fibroblasts
- Jiunn-Min Shieh
- , Yih-Jeng Tsai
- & Wen-Bin Wu
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Article
| Open Access5-Methylcytosine immunohistochemistry for predicting cutaneous melanoma prognosis
- Jiraroch Meevassana
- , Shananya Varophas
- & Nakarin Kitkumthorn
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Article
| Open AccessA new DNA aptamer which binds to SARS-CoV-2 spike protein and reduces pro-inflammatory response
- Woong Kim
- , Eun Su Song
- & Seok-Jun Kim
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Article
| Open AccessCardiometabolic profiles and proteomics associated with obesity phenotypes in a longitudinal cohort of young adults
- Jiawen Liao
- , Jesse A. Goodrich
- & Zhanghua Chen
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Article
| Open AccessVaginal microbiomes of breast cancer survivors treated with aromatase inhibitors with and without vulvovaginal symptoms
- Pimpun Prasanchit
- , Pisut Pongchaikul
- & Jittima Manonai
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Article
| Open AccessVitamin D3 deficiency and osteopenia in spastic paraplegia type 5 indicate impaired bone homeostasis
- Sabrina Ehnert
- , Stefan Hauser
- & Tim W. Rattay
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Article
| Open AccessLentiviral mediated delivery of CRISPR/Cas9 reduces intraocular pressure in a mouse model of myocilin glaucoma
- Shruti V. Patil
- , Balasankara Reddy Kaipa
- & Gulab S. Zode
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Article
| Open AccessA highly selective mPGES-1 inhibitor to block abdominal aortic aneurysm progression in the angiotensin mouse model
- Lauren M. Weaver
- , Madeline J. Stewart
- & Chang-Guo Zhan
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Article
| Open AccessBalanced activation of Nrf-2/ARE mediates the protective effect of sulforaphane on keratoconus in the cell mechanical microenvironment
- Ruixing Liu
- , Ruojun Ma
- & Xiaoming Yan
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Article
| Open AccessN-benzyl-N-methyldecan-1-amine, derived from garlic, and its derivative alleviate 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in mice
- Ji Eun Kim
- , Phatcharaporn Budluang
- & Young-Hwa Chung
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Article
| Open AccessLysine demethylase LSD1 is associated with stemness in EBV-positive B cell lymphoma
- Joo Hyun Kim
- , Chaehwa Park
- & Won Seog Kim
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Article
| Open AccessExtracellular vesicles secreted from mesenchymal stem cells ameliorate renal ischemia reperfusion injury by delivering miR-100-5p targeting FKBP5/AKT axis
- Guo Chen
- , Xinyuan Li
- & Yuanbin Jiang
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Article
| Open AccessEstimate the burden of malnutrition among children with cerebral palsy in Sub-Saharan Africa: a systematic review with meta-analysis
- Ermias Sisay Chanie
- , Natnael Moges
- & Sewunt Sisay Chanie
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Article
| Open AccessRaman spectroscopy of lymphocytes from patients with the Epstein–Barr virus infection
- Magdalena Pietruszewska
- , Grażyna Biesiada
- & Aleksandra Wesełucha-Birczyńska
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Article
| Open AccessIdentification of Hedyotis diffusa Willd-specific mRNA–miRNA–lncRNA network in rheumatoid arthritis based on network pharmacology, bioinformatics analysis, and experimental verification
- Jing Jiang
- , Meng Huang
- & Wen-Kui Sun
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Article
| Open AccessHybrid similarity relation based mutual information for feature selection in intuitionistic fuzzy rough framework and its applications
- Anoop Kumar Tiwari
- , Rajat Saini
- & Mohd Asif Shah
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Article
| Open AccessIdentifying key antioxidative stress factors regulating Nrf2 in the genioglossus with human umbilical cord mesenchymal stem-cell therapy
- Haixian Guo
- , Yue Liu
- & Dan Yu
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Article
| Open AccessGenetic diversity of variants involved in drug response among Tunisian and Italian populations toward personalized medicine
- Haifa Jmel
- , Stefania Sarno
- & Rym Kefi
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Article
| Open AccessAmmonia is associated with liver-related complications and predicts mortality in acute-on-chronic liver failure patients
- Kessarin Thanapirom
- , Sombat Treeprasertsuk
- & Shiv Kumar Sarin
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Article
| Open AccessDecreased AdipoR1 signaling and its implications for obesity-induced male infertility
- Toshiko Kobori
- , Masato Iwabu
- & Masato Kasuga
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Article
| Open AccessHigh inflammatory cytokines gene expression can be detected in workers with prolonged exposure to silver and silica nanoparticles in industries
- Vahid Babaei
- , Azadeh Ashtarinezhad
- & Farshad H. Shirazi