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Pain is an unpleasant sensory and emotional experience. Acute nociceptive pain is induced by noxious stimuli, and is often a result of an intense or potentially damaging stimulus.
Nocebo hyperalgesia can be socially transmitted through a chain of observers. Differences in interpersonal physiological and psychological synchrony predicted subsequent socially-acquired pain.
The mechanism underlying mechanical hyperalgesia is not fully understood. Here authors show opposing roles of tactile afferents in mechanical nociception using mouse pain models.
The voltage-gated sodium channel Nav1.7 is expressed on chondrocytes, regulates chondrocyte biology and osteoarthritis progression, and is a promising dual target for modifying disease while providing pain relief in osteoarthritis.
A focus on maternal mortality reduction and time-restricted follow-ups after childbirth has led to neglect of long-term labor and birth complications experienced by women.
VX-548 selectively inhibits peripheral sodium channels to reduce acute pain, with potentially fewer safety concerns than for existing, nonselective blockers.
A new report indicates that low back pain remains the leading cause of disability worldwide, and that case numbers are expected to increase substantially in the coming decades.