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| Open AccessRare variant associations with plasma protein levels in the UK Biobank
A set of three papers in Nature reports a new proteomics resource from the UK Biobank and initial analysis of common and rare genetic variant associations with plasma protein levels.
- Ryan S. Dhindsa
- , Oliver S. Burren
- & Slavé Petrovski
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An atlas of genetic scores to predict multi-omic traits
A machine learning approach is used to analyse multi-omics (proteomics, metabolomics and transcriptomics) data, producing genetic scores for more than 17,000 biomolecular traits in human blood, and identifying possible associations with disease.
- Yu Xu
- , Scott C. Ritchie
- & Michael Inouye
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Article
| Open AccessA saturated map of common genetic variants associated with human height
A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.
- Loïc Yengo
- , Sailaja Vedantam
- & Joel N. Hirschhorn
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MC3R links nutritional state to childhood growth and the timing of puberty
MC3R deficiency is associated with a delay in the onset of puberty, and a reduction in growth and lean mass.
- B. Y. H. Lam
- , A. Williamson
- & S. O’Rahilly
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Article
| Open AccessGenome-wide association studies of brain imaging phenotypes in UK Biobank
Genome-wide association studies of brain imaging data from 8,428 individuals in UK Biobank show that many of the 3,144 traits studied are heritable, and genes associated with individual phenotypes are identified.
- Lloyd T. Elliott
- , Kevin Sharp
- & Stephen M. Smith
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Genomic atlas of the human plasma proteome
A genetic atlas of the human plasma proteome, comprising 1,927 genetic associations with 1,478 proteins, identifies causes of disease and potential drug targets.
- Benjamin B. Sun
- , Joseph C. Maranville
- & Adam S. Butterworth
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Letter |
Mutation predicts 40 million years of fly wing evolution
A detailed analysis of fly wing phenotypes reveals a strong positive relationship between variation produced by mutation, standing genetic variation, and evolutionary rate over the past 40 million years.
- David Houle
- , Geir H. Bolstad
- & Thomas F. Hansen
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Letter |
Genetic wiring maps of single-cell protein states reveal an off-switch for GPCR signalling
Random mutagenesis in haploid human cells coupled to quantitative protein measurements with different antibodies is used as a readout for individual cellular phenotypes.
- Markus Brockmann
- , Vincent A. Blomen
- & Thijn R. Brummelkamp
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The genetic basis of parental care evolution in monogamous mice
Parental care in mice evolves through multiple genetic changes; one candidate is vasopressin, the reduced expression of which promotes parental nest-building behaviour in monogamous mice.
- Andres Bendesky
- , Young-Mi Kwon
- & Hopi E. Hoekstra
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Letter |
Genome-wide associations for birth weight and correlations with adult disease
Multi-ancestry genome-wide association analyses for birth weight in 153,781 individuals identified 60 genomic loci in which birth weight and fetal genotype were associated and found an inverse genetic correlation between birth weight and cardiometabolic risk.
- Momoko Horikoshi
- , Robin N. Beaumont
- & Rachel M. Freathy
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Defining the consequences of genetic variation on a proteome-wide scale
The effect of natural genetic diversity on the proteome is characterized using an outbred mouse model with extensive variation; both transcripts and proteins from mouse livers are quantified to identify a large set of protein quantitative trait loci (pQTL), and mediation analysis identifies causal protein intermediates of distant pQTL.
- Joel M. Chick
- , Steven C. Munger
- & Steven P. Gygi
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Letter |
The temporal scaling of Caenorhabditis elegans ageing
A diverse range of molecular and genetic manipulations all alter lifespan distributions of Caenorhabditis elegans by an apparent stretching or shrinking of time.
- Nicholas Stroustrup
- , Winston E. Anthony
- & Walter Fontana
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Letter |
Selection on noise constrains variation in a eukaryotic promoter
Quantifying activity of cis-regulatory sequences controlling gene expression shows that selection on expression noise has a greater impact on sequence variation than selection on mean expression level.
- Brian P. H. Metzger
- , David C. Yuan
- & Patricia J. Wittkopp
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Letter |
Genetics of single-cell protein abundance variation in large yeast populations
A new method for identifying genetic loci that influence protein expression in budding yeast reveals considerable complexity in how genetic variation shapes the proteome.
- Frank W. Albert
- , Sebastian Treusch
- & Leonid Kruglyak
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Letter |
Variation and genetic control of protein abundance in humans
A large-scale analysis of variation in human protein levels between individuals is performed using mass-spectrometry-based proteomic technology, and a number of protein quantitative trait loci are identified; over 5% of proteins vary by more than 1.5-fold in their expression levels between individuals, and this variation is not always linked to RNA level.
- Linfeng Wu
- , Sophie I. Candille
- & Michael Snyder
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Genomic analysis of a key innovation in an experimental Escherichia coli population
By combining full-genome sequencing and ‘evolutionary replay’ experiments to dissect the origin of aerobic citrate use in an experimental Escherichia coli population over 40,000 generations and 2 decades, the authors unveil a 3-step process in which potentiation makes a trait possible, actualization makes the trait manifest and refinement makes it effective.
- Zachary D. Blount
- , Jeffrey E. Barrick
- & Richard E. Lenski
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