Featured
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Article |
RNA editing underlies genetic risk of common inflammatory diseases
cis-RNA editing quantitative trait loci, which are associated with immunogenic double-stranded RNAs, underlie genome-wide association study variants in common autoimmune and inflammatory diseases.
- Qin Li
- , Michael J. Gloudemans
- & Jin Billy Li
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Article |
Breakage of cytoplasmic chromosomes by pathological DNA base excision repair
DNA damage during chromothripsis is caused by deoxyinosine formation on accumulated RNA–DNA hybrids in micronuclei that are then recognized by N-methyl-purine DNA glycosylase and cleaved by apurinic/apyrimidinic endonuclease.
- Shangming Tang
- , Ema Stokasimov
- & David Pellman
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Letter |
Dynamic landscape and regulation of RNA editing in mammals
Using the GTEx data and others, a comprehensive analysis of adenosine-to-inosine RNA editing in mammals is presented; targets of the various ADAR enzymes are identified, as are several potential regulators of editing, such as AIMP2.
- Meng How Tan
- , Qin Li
- & Jin Billy Li
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Letter |
CPEB1 coordinates alternative 3′-UTR formation with translational regulation
CPEB1 is known to regulate cytoplasmic polyadenylation, and is now shown to have a second function in the nucleus; it associates with the cleavage and polyadenylation machinery, thereby promoting usage of an upstream poly(A) signal in many messenger RNAs, and affecting alternative splicing.
- Felice-Alessio Bava
- , Carolina Eliscovich
- & Raúl Méndez
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News |
RNA editing study under intense scrutiny
Debate highlights pitfalls in interpreting genomic data.
- Erika Check Hayden
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News |
Evidence of altered RNA stirs debate
Sceptics question find that upends biology's 'central dogma'.
- Erika Check Hayden
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News |
Cells may stray from 'central dogma'
The ability to edit RNA to produce 'new' protein-coding sequences could be widespread in human cells.
- Erika Check Hayden
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News |
DNA sequence may be lost in translation
Researchers tackle a mysterious genetic phenomenon
- Alla Katsnelson