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A spinal cord injury consists of damage to the spinal cord that results from external trauma including accidents, falls and sports-related injuries, rather than a degenerative disease. The effects of a spinal cord injury widely vary from no effect, to pain, or to complete loss of spinal cord function.
In the CELLTOP Phase I trial, stem cells were harvested from patients with spinal cord injury and injected into their central nervous system after processing. The procedure was safe, with no reported serious adverse events during the 2-year follow-up period.
Electrical signals with characteristic parameters for reconstructing neural circuits remain incompletely understood, limiting the therapeutic potential of electrical neuromodulation techniques. Here, the authors demonstrate that dual electrical stimulation at 10–20 Hz rebuilds the spinal sensorimotor neural circuit after spinal cord injury, indicating the characteristic signals of circuit remodeling.
Spiny mice (Acomys cahirinus) are revealed to recover motor co-ordination following complete spinal cord transection, owing to regrowth of axonal motor pathways across the lesion site.
Regenerative neurogenesis after spinal cord injury in zebrafish involves TNF signalling between lesion-activated macrophages and spinal progenitor cells.