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| Open AccessRNA-mediated demixing transition of low-density condensates
The cell interior is organized by diverse membrane-less condensates. Here, the authors reveal that the densities of certain condensates are surprisingly low, similar to the surrounding protoplasm and driven by cellular RNA as well as the crowded milieu.
- Taehyun Kim
- , Jaeyoon Yoo
- & Yongdae Shin
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Article
| Open AccessLsm7 phase-separated condensates trigger stress granule formation
Stress granules are non-membranous organelles connected to stress responses and age-related disease. Here, the authors identify a conserved yeast protein, Lsm7, that facilitates stress granule formation through dynamic liquid-liquid phase separation condensates upon 2-deoxy-D-glucose-induced stress.
- Michelle Lindström
- , Lihua Chen
- & Beidong Liu
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Article
| Open AccessThe prion-like protein kinase Sky1 is required for efficient stress granule disassembly
The factors regulating stress granule dissolution are not fully understood. Here, the authors identify Sky1 as a stress granule component in yeast, and show that Sky1 kinase activity is required for timely stress granule disassembly during stress recovery.
- Jenifer E. Shattuck
- , Kacy R. Paul
- & Eric D. Ross
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Article
| Open AccessStructural basis for reversible amyloids of hnRNPA1 elucidates their role in stress granule assembly
Low complexity (LC) domains can drive the formation of both amyloid fibrils and protein droplets. Here, the authors identify reversible amyloid cores from the LC of hnRNPA1, based on which they elucidate the structural basis of reversible fibrillation and its interplay with hnRNPA1 droplet formation.
- Xinrui Gui
- , Feng Luo
- & Dan Li
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Article
| Open AccessStress-dependent miR-980 regulation of Rbfox1/A2bp1 promotes ribonucleoprotein granule formation and cell survival
Rbfox1, a pro-survival RNA-binding protein, is expressed in a complex manner and mediates diverse developmental processes. Here, the authors observe alternative splicing of Rbfox1 and stress-dependent regulation by miR-980 in Drosophila ovaries and Rbfox1 localisation in ribonucleoprotein granules in human cells.
- Mariya M. Kucherenko
- & Halyna R. Shcherbata
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Article
| Open AccessNEDDylation promotes stress granule assembly
Stress granules that form in response to stress contain translationally stalled mRNPs and play important roles in cellular homeostasis. Here the authors implicate SRSF3 neddylation as an important factor in the formation of stress granules in response to arsenite exposure.
- Aravinth Kumar Jayabalan
- , Anthony Sanchez
- & Takbum Ohn