Abstract
IT was found by two of us1 that salicylhydroxamic acid completely inhibits growth of some pathogenic fungi (Trichophyton schoenleinii, T. gypseum, T. rubrum, T. violaceum) in vitro at a concentration of 0.025–0.1 per cent (0.25–1.0 mgm. per 1 ml.). A similar effect was produced by benzohydroxamic acid and 2-hydroxy-3-naphthydroxamic acid2. It was interesting to find that 5-bromosalicylhydroxamic acid (‘T 40’)3 (which has now found clinical application in Poland as an auxiliary remedy in treating tuberculosis in addition to ‘INH’4) possesses a very low fungistatic activity.
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References
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ALKIEWICZ, J., ECKSTEIN, Z., HALWEG, H. et al. Fungistatic Activity of some Hydroxamic Acids. Nature 180, 1204–1205 (1957). https://doi.org/10.1038/1801204a0
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DOI: https://doi.org/10.1038/1801204a0
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