Abstract
d-TUBOCURARINE and its dimethyl ether have established places for themselves as muscle relaxants in anæsthesia. It is therefore of practical as well as theoretical importance to investigate the curarizing properties of synthetic compounds which are very closely related to these curare derivatives. In a previous communication1, we showed that decamethylene-αω-bis-6:7:8-trimethoxy-1.2.3.4-tetrahydro-iso-quinolinium methiodide (compound 15) possesses activity approaching that of d-O.O-dimethyltubocurarine in the rabbit, and we have pointed out the strong chemical resemblance between the two substances.
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References
Taylor, E. P., and Collier, H. O. J., Nature, 165, 602 (1950).
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Paton, W. D. M., and Zaimis, E. J., Brit. J. Pharmacol., 4, 381 (1949).
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TAYLOR, E., COLLIER, H. Synthetic Curarizing Agents structurally related to d-O.O-Dimethyltubocurarine. Nature 167, 692–693 (1951). https://doi.org/10.1038/167692a0
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DOI: https://doi.org/10.1038/167692a0
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