Abstract
THE introduction of anhydro-oxy-progesterone (pregneninolone, ethinyl-testosterone) by Inhoffen and Hohlweg1 and Ruzicka, Hofmann and Meldahl2, and the demonstration by the former authors of its high progesterone-like activity when given by mouth, opens up the possibility of an important advance in endocrine therapy (see, for example, Zondek and Rozin3); but its multiple biological properties also make the substance of considerable theoretical interest.
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References
Inhoffen, H. H., and Hohlweg, W., Naturwiss., 26, 96 (1938).
Ruzicka, L., Hofmann, K., and Meldahl, H. F., Helv. chim. Acta, 21, 372 (1938).
Zondek, B., and Rozin, S., Lancet, i, 504, No. 9 (1939).
McPhail, M. K., J. Physiol., 82, 145 (1934).
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EMMENS, C., PARKES, A. Multiple Activities of Anhydro-oxy-progesterone. Nature 143, 1064 (1939). https://doi.org/10.1038/1431064a0
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DOI: https://doi.org/10.1038/1431064a0
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