Abstract
IN previous reports1,2 concerning the mechanism of inhibition of D-amino-acid oxidase, the formation of a complex of the inhibitor and the coenzyme, flavin adenine dinucleotide, was described. Experiments with chlorpromazine, however, indicated a different mechanism of inhibition.
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References
Yagi, K., Okuda, J., Ozawa, T., and Okada, K., Science, 124, 273 (1956); Biochim. Biophys. Acta (in the press).
Yagi, K., Okuda, J., Ozawa, T., and Okada, K., Biochem. Z., 328, 492 (1957).
Yagi, K., Nagatsu, T., and Ozawa, T., Nature, 177, 891 (1956).
Szent-Györgyi, A., ‘Bioenergetics’, 118 (Academic Press, 1957).
Yagi, K., Ozawa, T., Ando, M., and Nagatsu, T., (unpublished results).
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YAGI, K., OZAWA, T. & NAGATSU, T. Complex Formation of Chlorpromazine with Flavins. Nature 184, 982–983 (1959). https://doi.org/10.1038/184982a0
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DOI: https://doi.org/10.1038/184982a0
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