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Steric Course of the Succinic Dehydrogenase Catalysed Exchange of Hydrogen between Succinate and Water

Nature volume 216, pages 1320–1321 (1967)Cite this article

Abstract

SUCCINIC dehydrogenase (succinate: (acceptor) oxido-reductase E.C. 1.3.99.1) catalyses the oxidation of succinate by various electron acceptors to fumarate. Although the mechanism of the reaction is not yet understood, it has been shown1 that the overall process involves removal of one HR- and one HS-atom2 from adjacent carbon atoms of the substrate (Fig. 1a); this corresponds to a trans elimination from the antiperiplanar conformation of succinate, as in Fig. 1b.

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References

  1. Tchen, T. T., and van Milligan, H., J. Amer. Chem. Soc., 82, 4115 (1960).

    Article  CAS  Google Scholar 

  2. Weber, H., Seibl, J., and Arigoni, D., Helv. Chim. Acta, 49, 741 (1966); Hanson, K. R., J. Amer. Chem. Soc., 88, 2731 (1966).

    Article  CAS  Google Scholar 

  3. Weinmann, E. O., Morehouse, M. G., and Winzler, R. J., J. Biol. Chem., 168, 717 (1947).

    CAS  PubMed  Google Scholar 

  4. Englard, S., and Colowick, S. P., J. Biol. Chem., 221, 1019 (1956).

    CAS  PubMed  Google Scholar 

  5. Gawron, O., Glaid, A. J., and Francisco, J., Biochem. Biophys. Res. Commun., 16, 156 (1964).

    Article  CAS  Google Scholar 

  6. Cornforth, J. W., Ryback, G., Popják, G., Donninger, C., and Schroepfer, jun., G., Biochem. Biophys. Res. Commun., 9, 371 (1962).

    Article  CAS  Google Scholar 

  7. Gawron, O., Glaid, A. J., Mahajan, K., Kananen, G., and Limetti, M., Biochem. Biophys. Res. Commun., 25, 518 (1966).

    Article  CAS  Google Scholar 

  8. Kahn, J., and Rittenberg, D., Biochem. Biophys. Res. Commun., 27, 484 (1967).

    Article  CAS  Google Scholar 

  9. DerVartanian, D. V., and Veeger, C., Biochim. Biophys. Acta, 92, 233 (1964).

    CAS  PubMed  Google Scholar 

  10. Busch, H., Hurlbert, R. B., and Potter, V. R., J. Biol. Chem., 196, 717 (1952).

    CAS  PubMed  Google Scholar 

  11. Childs, jun., C. R., and Bloch, K., J. Org. Chem., 26, 1630 (1961).

    Article  CAS  Google Scholar 

  12. Hüfner, M., Buckley, L. M., and Hollocher, T. C., Biochem. Biophys. Res. Commun., 28, 791 (1967).

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. Organisch-chemisches Laboratorium, Eidgenössische Technische Hochschule, Zürich

    J. RÉTEY, J. SEIBL & D. ARIGONI

  2. “Shell” Research Limited, Milstead Laboratory of Chemical Enzymology, Sittingbourne

    J. W. CORNFORTH & G. RYBACK

  3. Laboratory of Biochemistry, BCP Jansen Institute, University of Amsterdam, Amsterdam

    W. P. ZEYLEMAKER

  4. Department of Biochemistry, Agricultural University, Wageningen

    C. VEEGER

Authors
  1. J. RÉTEY
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RÉTEY, J., SEIBL, J., ARIGONI, D. et al. Steric Course of the Succinic Dehydrogenase Catalysed Exchange of Hydrogen between Succinate and Water. Nature 216, 1320–1321 (1967). https://doi.org/10.1038/2161320a0

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