Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Fluorocarbon anaesthetics break hydrogen bonds

Abstract

MANY fluorocarbon derivatives that contain higher halogens dissociate hydrogen bonds of the N–H—N, O–H—O, S–H—S, N–H—O=C type which are similar to those occurring in living organisms. A parallelism exists between this property of fluorocarbons and their anaesthetic potency. Their interference with cell division might also be related to it.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Krantz, J. C., and Rudo, F. G., Handbook of Experimental Pharmacology, XX/I (edit. by Smith, F. A.), 501–564 (Springer, Berlin, 1966).

    Google Scholar 

  2. Larsen, E. R., Fluorine Chem. Rev., 3, 1 (1969).

    CAS  Google Scholar 

  3. Clayton, J. W., Fluorine Chem. Rev., 1(2), 197 (1967).

    CAS  Google Scholar 

  4. Meyer, H., and Hemmi, H., Biochem. Z., 277, 39 (1935).

    CAS  Google Scholar 

  5. Seeman, P., Pharmac. Rev., 24, 583 (1972).

    CAS  Google Scholar 

  6. Pauling, L., Science, 134, 15 (1961).

    Article  ADS  CAS  Google Scholar 

  7. Miller, S. L., Proc. natn. Acad. Sci. U.S.A., 47, 1515 (1961).

    Article  ADS  CAS  Google Scholar 

  8. Nunn, J. F., Acta anaesth. scand., 16, 169 (1972).

    Article  CAS  Google Scholar 

  9. Ueda, I., and Kamaya, H., Anesthesiology, 38, 425 (1973).

    Article  CAS  Google Scholar 

  10. Eyring, H., Woodbury, J. W., and D'Arrigo, J. S., Anesthesiology, 38, 415 (1973).

    Article  CAS  Google Scholar 

  11. Bernard-Houplain, M.-C., Bourdéron, C., Péron, J.-J., and Sandorfy, C., Chem. Phys. Lett., 11, 149 (1971).

    Article  ADS  CAS  Google Scholar 

  12. Bernard-Houplain, M.-C., and Sandorfy, C., Can. J. Chem., 51, 3640 (1973).

    Article  CAS  Google Scholar 

  13. Nunn, J. F., Lovis, J. D., and Kimball, K. L., Br. J. Anaesth., 43, 524 (1971).

    Article  CAS  Google Scholar 

  14. Jackson, S. H., Anesthesiology, 39, 405 (1973).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

DI PAOLO, T., SANDORFY, C. Fluorocarbon anaesthetics break hydrogen bonds. Nature 252, 471–472 (1974). https://doi.org/10.1038/252471a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/252471a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing