Aicardi-Goutières syndrome (AGS) is an autosomal recessive condition of progressive encephalopathy of early childhood, very similar to congenital viral infections. Two new papers identify four genes mutated in AGS and implicate the processing of DNA and RNA by-products in its pathogenesis.
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Alarcón-Riquelme, M. Nucleic acid by-products and chronic inflammation. Nat Genet 38, 866–867 (2006). https://doi.org/10.1038/ng0806-866
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DOI: https://doi.org/10.1038/ng0806-866
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