Hyperactivation of receptor tyrosine kinase pathways is a common theme in cancer. The recent demonstration that an imbalance between the fibroblast growth factor receptor 2–binding proteins Grb2 and phospholipase C-γ1 can lead to invasive behavior in the absence of growth factors highlights an emerging concept in cellular-signaling homeostasis.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$189.00 per year
only $15.75 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Timsah, Z. et al. Nat. Struct. Mol. Biol. 21, 180–188 (2014).
Turner, N. & Grose, R. Nat. Rev. Cancer 10, 116–129 (2010).
Ahmed, Z. et al. J. Cell Biol. 200, 493–504 (2013).
Lin, C.C. et al. Cell 149, 1514–1524 (2012).
Lemmon, M.A. & Schlessinger, J. Cell 141, 1117–1134 (2010).
Wienken, C.J., Baaske, P., Rothbauer, U., Braun, D. & Duhr, S. Nat. Commun. 1, 100 (2010).
Zhang, X. et al. J. Biol. Chem. 281, 15694–15700 (2006).
Belleudi, F., Purpura, V. & Torrisi, M.R. PLoS ONE 6, e24194 (2011).
Bunney, T.D. et al. Structure 20, 2062–2075 (2012).
Ahmed, Z. et al. Cell. Signal. 22, 23–33 (2010).
Bleasdale, J.E. et al. Adv. Prostaglandin Thromboxane Leukot. Res. 19, 590–593 (1989).
Sala, G. et al. Cancer Res. 68, 10187–10196 (2008).
Fearon, A.E., Gould, C.R. & Grose, R.P. Int. J. Biochem. Cell Biol. 45, 2832–2842 (2013).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Fearon, A., Grose, R. Grb-ing receptor activation by the tail. Nat Struct Mol Biol 21, 113–114 (2014). https://doi.org/10.1038/nsmb.2767
Published:
Issue Date:
DOI: https://doi.org/10.1038/nsmb.2767
This article is cited by
-
Anti-fibrotic effects of pharmacologic FGF-2: a review of recent literature
Journal of Molecular Medicine (2022)
-
Advances and challenges in targeting FGFR signalling in cancer
Nature Reviews Cancer (2017)