The dogma that self-renewal is a defining characteristic of stem cells, which stemmed from studies of the hematopoietic hierarchy and quickly spread by analogy to all tissues, has been shattered by scientists pointing a microscope at the hematopoietic system itself. A microglial cell is clearly fully differentiated, and yet it self-renews.
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References
Huang, Y. et al. Nat. Neurosci. https://doi.org/10.1038/s41593-018-0090-8 (2018).
Elmore, M. R. P. et al. Neuron 82, 380–397 (2014).
Ajami, B., Bennett, J. L., Krieger, C., Tetzlaff, W. & Rossi, F. M. V. Nat. Neurosci. 10, 1538–1543 (2007).
Ajami, B., Bennett, J. L., Krieger, C., McNagny, K. M. & Rossi, F. M. V. Nat. Neurosci. 14, 1142–1149 (2011).
Göritz, C. et al. Science 333, 238–242 (2011).
Kaur, C., Hao, A.-J., Wu, C.-H. & Ling, E.-A. Microsc. Res. Tech. 54, 2–9 (2001).
Goldmann, T. et al. Nat. Neurosci. 16, 1618–1626 (2013).
del Río Hortega, P. in The Cytology and Cellular Pathology of the Nervous System (ed. Penfield, W.) 482–534 (Hoeber, New York, 1932).
Cuadros, M. A., Moujahid, A., Quesada, A. & Navascués, J. J. Comp. Neurol. 348, 207–224 (1994).
Kierdorf, K. et al. Nat. Neurosci. 16, 273–280 (2013).
Yoon, H., Kim, T. S. & Braciale, T. J. PLoS One 5, e15423 (2010).
Kachinsky, A. M., Dominov, J. A. & Miller, J. B. Dev. Biol. 165, 216–228 (1994).
Méndez-Ferrer, S. et al. Nature 466, 829–834 (2010).
Bruttger, J. et al. Immunity 43, 92–106 (2015).
Krishnasamy, S. et al. J. Neuroinflammation 14, 45 (2017).
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Rossi, F., Lewis, C. Microglia’s heretical self-renewal. Nat Neurosci 21, 455–456 (2018). https://doi.org/10.1038/s41593-018-0123-3
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DOI: https://doi.org/10.1038/s41593-018-0123-3
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