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Showing 1–32 of 32 results

    • Alison Schuldt
    Research Highlights
    Nature Reviews Molecular Cell Biology
    Volume: 12, P: 693

    • Grant Miura
    Research Highlights
    Nature Chemical Biology
    Volume: 11, P: 632

  • Cep135, Ana1 (Cep295) and Asterless (Cep152) are sequentially recruited to daughter centrioles to enable their maturation into duplication-competent mother centrioles.

    • Paulina Strzyz
    Research Highlights
    Nature Reviews Molecular Cell Biology
    Volume: 17, P: 4

    • Grant Miura
    Research Highlights
    Nature Chemical Biology
    Volume: 11, P: 448

  • ESCRT-III seals holes in the nuclear envelope (NE). A study now shows that the Cmp7-directed ESCRT-III cascade that grommets and reseals NE holes after spindle pole body (SPB) extrusion at the end of fission yeast mitosis is complemented by the presence of a proteinaceous diffusion barrier to ensure NE integrity.

    • Hiral Shah
    • Gautam Dey
    News & Views
    Nature Cell Biology
    Volume: 25, P: 1411-1412

  • Three independent studies provide molecular insights into the mechanism governing cell cycle arrest in response to centrosome loss.

    • Paulina Strzyz
    Research Highlights
    Nature Reviews Molecular Cell Biology
    Volume: 17, P: 536

  • Phosphatase PP2A regulates centriole assembly inC. elegansembryos.

    • Rachel David
    Research Highlights
    Nature Reviews Molecular Cell Biology
    Volume: 12, P: 342

  • FBXW5 regulates centrosome duplication and is itself controlled by APC/C and PLK4.

    • Rachel David
    Research Highlights
    Nature Reviews Molecular Cell Biology
    Volume: 12, P: 466-467

  • Centrosomes can nucleate not only microtubules but also actin filaments, in a process dependent on the actin-related protein 2/3 complex and WASH.

    • Paulina Strzyz
    Research Highlights
    Nature Reviews Molecular Cell Biology
    Volume: 17, P: 66-67

  • A novel function for CaMKIIβ has been identified in the mammalian brain whereby it regulates dendritic patterning through phosphorylation of CDC20–APC/C at the centrosome.

    • Sian Lewis
    Research Highlights
    Nature Reviews Neuroscience
    Volume: 12, P: 493

  • Two distinct regions in ORC1 control centrosome copy number and DNA replication.

    • Kim Baumann
    Research Highlights
    Nature Reviews Molecular Cell Biology
    Volume: 13, P: 542

  • Clathrin heavy chain 17 promotes centrosome maturation at the onset of mitosis.

    • Kim Baumann
    Research Highlights
    Nature Reviews Molecular Cell Biology
    Volume: 13, P: 606

  • Clues into how newly formed procentrioles emerge at a right angle from the mother centriole.

    • Renata Basto
    Research Highlights
    Nature Reviews Molecular Cell Biology
    Volume: 13, P: 686

  • SAS-6 oligomerization provides a structural basis for the ninefold symmetry of centrioles.

    • Alison Schuldt
    Research Highlights
    Nature Reviews Molecular Cell Biology
    Volume: 12, P: 137

  • ARPC1B is a novel activator and substrate of Aurora A kinase.

    • Mhairi Skinner
    Research Highlights
    Nature Reviews Molecular Cell Biology
    Volume: 11, P: 543

  • Overload of proteasomal clearance triggers formation of a large protein inclusion called the aggresome, which shares similarities with protein aggregates seen in neurodegenerative diseases such as Huntington’s. A new study uncovers how centrosome and centriolar satellite components facilitate stepwise assembly of aggresomes.

    • Elisa Vitiello
    • Fanni Gergely
    News & Views
    Nature Cell Biology
    Volume: 24, P: 408-410

  • Assembly of the mitotic spindle requires timely separation of the centrosomes. Their movement apart is driven by the plus-end-directed kinesin Eg5. A new study demonstrates that the kinesin KIFC3 provides an opposing microtubule-based cohesive force that modulates centrosome separation and ensures accurate chromosome segregation.

    • Ciaran G. Morrison
    News & Views
    Nature Cell Biology
    Volume: 21, P: 1057-1059

  • Two papers demonstrate that centrosome amplification can cause cancer in mammals and that a PIDDosome–p53-dependent control mechanism acts to prevent cell proliferation in the presence of extra centrosomes.

    • Anna Dart
    Research Highlights
    Nature Reviews Cancer
    Volume: 17, P: 143

  • Super-resolution microscopy reveals a conserved higher-order organization in pericentriolar material.

    • Kim Baumann
    Research Highlights
    Nature Reviews Molecular Cell Biology
    Volume: 13, P: 749

  • The microcephaly protein, Cep215, contributes to the engagement of duplicated centrioles in interphase. Now two distinct pools of Cep215 at centrosomes are identified, one bound to Cep68 and the other to pericentrin. Plk1-mediated degradation of Cep68 and separase-mediated cleavage of pericentrin release both pools of Cep215, thereby promoting centriole disengagement.

    • Andrew M. Fry
    News & Views
    Nature Cell Biology
    Volume: 17, P: 3-5

  • Centrioles are among the most beautiful of biological structures. How their highly conserved nine-fold symmetry is generated is a question that has intrigued cell biologists for decades. Two recent structural studies provide the tantalizing suggestion that the self-organizing properties of the SAS-6 protein hold the answer.

    • Matthew A Cottee
    • Jordan W Raff
    • Hélio Roque
    Comments & Opinion
    Nature Chemical Biology
    Volume: 7, P: 650-653

  • Centrosomes play an important role in Drosophila melanogaster stem cells, where the different size and activity of the two centrosomes help these cells divide asymmetrically. The molecular basis of the centrosome asymmetry has remained unclear, but new work highlights the centrosomal protein Centrobin as a key player in this process.

    • Paul T. Conduit
    News & Views
    Nature Cell Biology
    Volume: 15, P: 235-237

  • Centrioles duplicate only once per cell cycle in proliferating cells, whereas in multiciliated cells, hundreds of centrioles form almost simultaneously. The molecular control mechanisms that govern centriole amplification in multiciliated cells are largely unknown. Two studies highlight Deup1 and CCDC78 as key players in this process.

    • Tang K. Tang
    News & Views
    Nature Cell Biology
    Volume: 15, P: 1400-1402

  • Regulatory mechanisms to prevent centriole overduplication during the cell cycle are not completely understood. In this issue, FBXW5 is shown to control the degradation of the centriole assembly factor HsSAS-6. Moreover, the study proposes that FBXW5 is a substrate of both PLK4 and APC/C, two established regulators of centriole duplication.

    • Julia Pagan
    • Michele Pagano
    News & Views
    Nature Cell Biology
    Volume: 13, P: 888-890

  • The pericentriolar material (PCM), the microtubule-organizing component of the centrosome, contains a multitude of proteins and is commonly described as an amorphous cloud surrounding the centrioles. However, the days of the PCM as an unstructured matrix are numbered. Using super-resolution microscopy, several reports have now revealed remarkable domain organization within the PCM.

    • Jens Lüders
    News & Views
    Nature Cell Biology
    Volume: 14, P: 1126-1128

  • FOR20, a conserved centrosomal protein, is essential for Plk1 to localize to the centrosome during the S phase and regulate DNA replication. The absence of either Plk1 or FOR20 can stall the cell cycle by a previously unknown intra-S phase centrosomal checkpoint.

    • Ranadip Mandal
    • Klaus Strebhardt
    Research Highlights
    Cell Research
    Volume: 23, P: 1251-1253