Abstract
Peroxisome proliferator-activated receptors (PPAR) are transcription factors that regulate adipocyte differentiation and gene expression. We tested the hypothesis that the Pro12Ala variant of PPAR-γ2 is associated with obesity and type 2 diabetes-related traits in 921 subjects from the San Antonio Family Heart Study. Subjects with at least one Ala allele (n=210) had significantly higher body mass index (P=0.015) and waist circumference (P=0.028) and significantly higher levels of serum leptin (P=0.022) than those without the allele. Further studies will determine whether the Pro12Ala variant itself, or other genetic variation at PPAR-γ, is responsible for this association with measures of obesity in Mexican Americans.
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Acknowledgements
We are deeply grateful for the cooperation of the SAFHS participants. This work was supported by National Institutes of Health research grants PO1-HL45522 and RO1-AR43351. Support for the Frederic C. Bartter General Clinical Research Center was through Clinical National Institutes of Health Grant MO1-RR-01346.
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Cole, S., Mitchell, B., Hsueh, WC. et al. The Pro12Ala variant of peroxisome proliferator-activated receptor-γ2 (PPAR-γ2) is associated with measures of obesity in Mexican Americans. Int J Obes 24, 522–524 (2000). https://doi.org/10.1038/sj.ijo.0801210
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DOI: https://doi.org/10.1038/sj.ijo.0801210
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